Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against .

Over the last decade, has mutated into a putative 'superbug', as treatments against it have failed due to increasing antimicrobial resistance. As a result, the rising incidence of multidrug-resistant tuberculosis (MDR-TB) is posing a significant public health threat, thus, the need to develop effective drugs for MDR-TB has become an urgent priority. To identify new drug candidates for the treatment of MDR-TB, the present study was based on mycobacterial shikimate kinase (MtSK) as the pharmacological target.

Community practice of primary angioplasty for myocardial infarction.

Results obtained with primary angioplasty at the community level do not duplicate the results of the published trials. Major changes in current community practice patterns are needed to achieve the success rates of the published trials.

Does atrial fibrillation cause false-positive late potentials?

We hypothesized that atrial fibrillation may cause false-positive late potentials due to the recording of baseline atrial activity. We performed signal-averaged ECGs in 26 patients with atrial fibrillation before and after conversion to normal sinus rhythm. Signal-averaged ECGs were recorded for > 200 cycles with a noise level of < or = 0.