Childhood growth hormone treatment in women with Turner syndrome - benefits and adverse effects.

Turner syndrome (TS) is characterized by the partial or complete loss of one sex chromosome and results in growth failure, gonadal insufficiency and cardiac anomalies. Treatment with growth hormone (GH) during childhood has indisputable benefits when taking into account the low stature of TS women. Medical records and biochemical findings of 33 TS women treated with GH in childhood (GH+) were compared to those of 124 TS women who did not receive GH (GH-).

New insights into clinical features, karyotypes, and age at diagnosis in women with Turner syndrome.

Introduction: Turner syndrome (TS) is due to a chromosomal abnormality in which only one normal X chromosome is present. The purpose of the study was the assessment the prevalence of phenotypic differences in TS-women and monosomy-45,X and with other karyotypes as well as the possible relationship between the presence of differentiating features and age at final TS diagnosis.

Material And Methods: The prevalence of anomalies and abnormalities from history taking/physical examination of 157 TS-patients was compared to 25 healthy controls (age 27.

Social and medical determinants of quality of life and life satisfaction in women with Turner syndrome.

Background: Turner syndrome (TS) appears in women as a result of the lack of part or the whole of one of the X chromosomes. It is characterized by the occurrence of low height, hypogonadism, numerous developmental defects, and is often accompanied by psychological disturbances.

Objectives: Although the phenotype characteristics of women with TS are quite well documented, the knowledge of the impact of Turner syndrome on the satisfaction with life is still insufficient.

Selected clinical features of the head and neck in women with Turner syndrome and the 45,X/46,XY karyotype.

Introduction: A 45,X/46,XY karyotype in women with Turner syndrome (TS) is very rare. The presence of a Y chromosome in the karyotype causes phenotypic differences and increased risk for neoplastic disease, compared to TS-women with other karyotypes. Our study addresses an issue: non-genital phenotypic differences between TS-patients with a Y-chromosome of their karyotype and TS-women without it.

The cohort effect in studies related to differences in psychosocial functioning of women with Turner syndrome.

Introduction: The physical health deficits and psychological disorders of women with Turner syndrome (TS) are the deciding factors in their treatment, but also their own relation to their own and their family's experiences. This study aimed to find the differences in psychosocial functioning of TS women coming from two different generations. These differences show the cohort effect as change in personal functioning and quality of life.

The influence of hormonal replacement and growth hormone treatment on the lipids in Turner syndrome.

Aim: Women with Turner syndrome (TS) have a risk of developing cardiovascular diseases. We assessed the lipid and carbohydrate metabolism in TS-women in the context of current hormone replacement therapy (HRT) and growth hormone (GH) treatment during childhood.

Methods: The information were collected from medical documentation and anamnesis of 165 TS-women (24.

Mammary invasive ductal adenocarcinoma and vulvar invasive keratinizing squamous cell carcinoma in a woman with disseminated discoid lupus erythematosus (DDLE) - a case review.

A case of metachronous presentation of two malignancies, invasive mammary ductal adenocarcinoma and later invasive keratinizing squamous cell vulvar carcinoma, complicating a 20 years long course of disseminated discoid lupus erythematosus is described. The authors underline a potential role of long-standing immunotherapy as a factor responsible for inducing secondary neoplasia.

[The values of peripheral blood cell count parameters in women with Turner's syndrome].

Unlabelled: Turner's syndrome is a chromosomal anomaly which occurs in approximately one in 2500 females. The syndrome is characterized by the presence of primary gonadal dysgenesia which is manifested by, among others, amenorrhoea. Taking this fact into consideration, the values of blood cell count in Turner's syndrome women could have been expected to be better than the corresponding values in the general population of women.

[Height correlation analysis between women with Turner syndrome, their sisters and parents].

Introduction: The most frequent physical features associated with Turner syndrome is short stature. The main goal of the research was to estimate the height of women with Turner syndrome and to analyze the correlation between their height and their sisters and parents height.

Material And Methods: The research was based on the 176 women with Turner syndrome (number of parents = 176; number of sisters = 122).

[Selected problems of the diagnosis of Turner's syndrome].

Unlabelled: Turner's syndrome (TS) can be diagnosed in one out of 2130 females. The aim of the current study was to collect data about circumstances associated with the diagnosis of the syndrome. The material consisted of 177 female patients from the whole Polish territory, that turned to the out-patient Clinic for Women with Turner's syndrome, Specialist Hospital No 2 Bytom.

[Selected problems of the nephrological and urological status of women with Turner's syndrome].

Unlabelled: Nephrological and urological problems among women with Turner's syndrome (TS) have not been frequently investigated so far. The aim of our study was to address those issues in adult women with TS in Poland. 176 women with TS, whose age was between 18 and 51 years, who presented to our center from the whole territory of Poland between March, 1995 and December, 2002 were examined.

Are young women with Turner syndrome at greater risk of coronary artery disease?

Background: Turner syndrome is an X chromosome aberration that affects females. Women with Turner syndrome are exposed to a greater risk of coronary artery disease, arterial hypertension and type 2 diabetes mellitus.

Design: The objective of our study was to assess the prevalence of classic risk factors of coronary artery disease in young women with Turner syndrome in comparison to a representative group of Polish young women from the general population.

[Pregnancy in a woman with Turner syndrome--two new cases].

Pregnancies resulting from a spontaneous ovulation and fertilization are extremely rare in women with Turner syndrome. The majority of them end with abortion, still-born, or neonates with congenital defects. The article presents two women with Turner syndrome, mosaic karyotype 45,X/46,XX, who got pregnant without any medical intervention.

[Anorexia nervosa in woman with Turner's syndrome].

The authors report a case of anorexia nervosa in woman with Turner's syndrome (45, X). In this case there was a low blood concentration of LH and FSH, and there was a lack of reaction to intravenous administration of 100 micrograms of GnRH. Partial syndrome of "empty sella" was found in a presented case by use of magnetic resonance imaging.

[Radical vulvectomy using Way's method with bilateral removal of inguinal, thigh, iliac and veil lymph nodes in the clinic].

Thirty-one cards of women after radical vulvectomy in Way's mode were analysed. Metastases in inguinal, thigh, iliac and veil lymph nodes were found only in 19.35%.

[Serum monoamine oxidase (MAO) and diamine oxidase (DAO) activity and histamine level in the blood of women during the early puerperium].

In early puerperium various biochemical changes develop in the organism. Considering the role played by MAO, DAO and histamine, and absence of a comprehensive study of this problem in this life period a study was carried out on 36 women, who were selected randomly from women giving birth through the normal pathway. Blood samples were taken in morning hours on the 1, 2 and 3 days of puerperium.

Interaction on the antinociceptive effect between neurotensin and enkephalins or tuftsin.

The aim of this paper was to study the interaction between neurotensin and both enkephalins or its synthetic analogue D-Ala2-metenkephalinamide, or tuftsin, on the antinonciceptive effect of these peptides in mice after intracisternal injection. Antinociception was measured by the hot-plate method. It was shown that neurotensin antagonized evidently the antinociceptive effect of enkephalins and their analogue.

Effects of cholinomimetics, cholinolytics and atypical antidepressants in the behavioral despair test in the rat.

The effect of some cholinolytics, cholinomimetics and atypical antidepressants on behavior of rats forced to swim (in the "behavioral despair test") was investigated. In addition, the relation between the test performance and the inborn level of exploratory and locomotor activities was studied. Cholinomimetics prolonged, while cholinolytics and antidepressants shortened the immobility phase ("despair reaction").