Straightforward Synthesis of α-Chloromethylketimines Catalyzed by Gold(I). A Clean Way to Building Blocks.

α-Chloromethylketimines have been obtained through a gold-catalyzed hydroamination of aromatic and aliphatic 1-chloroalkynes with aromatic amines by using equimolar amounts of both reagents. This procedure has allowed the preparation and spectroscopic characterization of α-chloromethylketimines for the first time with a high degree of purity, complete conversion, and atom economy. The synthetic usefulness of the methodology has been demonstrated with the preparation of β-chloroamines and indoles.

Current Advances in Diazoles-based Chemosensors for CN- and FDetection.

Advances in molecular probes have recently intensified because they are valuable tools in studying species of interest for human health, the environment, and industry. Among these species, cyanide (CN-) and fluoride (F-) stand out as hazardous and toxic ions in trace amounts. Thus, there is a significant interest in probes design for their detection with diverse diazoles (pyrazole and imidazole) used for this purpose.