Significance of Impurity Analysis in Antiviral Drug: A Critical Review.

Today's pharmaceutical products are seeing a massive increase in impurity profiling. A drug substance or product will inevitably contain contaminants in trace amounts. According to pharmaceutical chemistry, impurities are undesirable substances found in pharmaceutical compounds with therapeutic activity.

A review of the physiological effects of microgravity and innovative formulation for space travelers.

During the space travel mission, astronauts' physiological and psychological behavior will alter, and they will start consuming terrestrial drug products. However, factors such as microgravity, radiation exposure, temperature, humidity, strong vibrations, space debris, and other issues encountered, the drug product undergo instability This instability combined with physiological changes will affect the shelf life and diminish the pharmacokinetic and pharmacodynamic profile of the drug product. Consequently, the physicochemical changes will produce a toxic degradation product and a lesser potency dosage form which may result in reduced or no therapeutic action, so the astronaut consumes an additional dose to remain healthy.

Effect of Anti-Retroviral Drug Impurity/Related Substances on the CCR5 and/or CXCR4 Receptors Binding Sites to Revise Resistance Mechanisms in the Clinical Implications Using Molecular Docking Studies.

Background: CCR5 and/or CXCR4 receptors on CD4+ T cell membranes are the active sites for HIV to bind. The different classes of drugs have a unique mechanism of action to cease the virus, but we are concentrating in the first-class i.e.

Sonic Hedgehog gene as a potential target for the early prophylactic detection of cancer.

In the search for newer and advanced methods for the detection of cancer, quicker and non-invasive techniques are imperative. One such potential approach for detection is the detection of oncogenes in the suspected tumour tissues. This search has led to the identification of the oncogene SHh, which is a key influencer in the tumourigenic pathways.

A Sensitive RP-HPLC Method for Simultaneous Estimation of Diethylcarbamazine and Levocetirizine in Tablet Formulation.

A simple, sensitive and reproducible method was developed and validated for the simultaneous estimation of diethylcarbamazine and levocetirizine in its tablet formulation by reverse phase high performance liquid chromatography using Waters1515 HPLC with UV detector at the λ(max) of 224 nm, using Princeton Sphere-100 C(18) (250×4.6 mm. 5 μ) column.