Rare cause of dyspnoea: phenazopyridine-induced methemoglobinemia.

Methemoglobinemia, due to the oxidation of iron from ferrous to ferric form in the haemoglobin molecule, results in decreased oxygen delivery to the tissues. Phenazopyridine, a commonly used medication for urinary symptoms, is a rare cause of methemoglobinemia. We report an elderly woman with advanced vaginal cancer, who developed methemoglobinemia following the use of phenazopyridine at a dose of 200 mg three times a day for 14 days.

Palliative care outpatients and improved documentation-what matters most? Quality improvement project.

Objective: Patients needs should be regularly assessed. We aimed to improve assessment and documentation of needs from baseline 25% in June 2022 to 75% in December 2022.

Methods: The A3, a structured problem-solving continuous-improvement methodology was used.

Erasmus syndrome: role of specialist palliative care.

Occupational exposure to silica has been seldom implicated to cause systemic sclerosis. Erasmus syndrome is a rare condition where there is development of systemic sclerosis following silicosis. Early diagnosis is essential for appropriate treatment and symptom control.

Quantitative focused laser differential interferometry with hypersonic turbulent boundary layers.

The effect of turbulent wind-tunnel-wall boundary layers on density change measurements obtained with focused laser differential interferometry (FLDI) was studied using a detailed direct numerical simulation (DNS) of the wall from the Boeing/AFOSR Mach-6 Quiet Tunnel run in its noisy configuration. The DNS was probed with an FLDI model that is capable of reading in three-dimensional time-varying density fields and computing the FLDI response. Simulated FLDI measurements smooth the boundary-layer root-mean-square (RMS) profile relative to true values obtained by directly extracting the data from the DNS.

100 kHz PLEET velocimetry in a Mach-6 Ludwieg tube.

Picosecond laser electronic-excitation tagging (PLEET) was demonstrated in a Mach-6 Ludwieg tube at a repetition rate of 100 kHz using a 1064 nm, 100 ps burst-mode laser. The system performance of high-speed velocimetry in unseeded air and nitrogen Mach-6 flows at a static pressure in the range of 5-20 torr were evaluated. Based on time-resolved freestream flow measurements and computational fluid dynamics (CFD) calculations, we concluded that the measurement uncertainty of 100 kHz PLEET measurement for Mach 6 freestream flow condition is ∼1%.