A Pyridazine-Based Fluorescent Probe Targeting A Plaques in Alzheimer's Disease.

Accumulation of -amyloid (A) plaques comprising A40 and A42 in the brain is the most significant factor in the pathogenesis of Alzheimer's disease (AD). Thus, the detection of A plaques has increasingly attracted interest in the context of AD diagnosis. In the present study, a fluorescent pyridazine-based dye that can detect and image A plaques was designed and synthesized, and its optical properties in the presence of A aggregates were evaluated.

A new class of cyclometalated ruthenium sensitizers of the type ĈNN for efficient dye-sensitized solar cells.

A new class of cyclometalated ruthenium sensitizers incorporating a ĈNN ligand and conjugated 2,2'-bipyridine in the ancillary ligand have been designed and synthesized. The photovoltaic performance of JK-206 using an electrolyte containing 0.6 M 1,2-dimethyl-3-propylimidazolium iodide, 0.

New efficient ruthenium sensitizers with unsymmetrical indeno[1,2-b]thiophene or a fused dithiophene ligand for dye-sensitized solar cells.

Two novel ruthenium sensitizers containing unsymmetrical indeno[1,2-b]thiophene or a fused dithiophene unit in the ancillary ligand have been designed and synthesized. The photovoltaic performance of JK-188 using an electrolyte consisting of 0.6 M 1,2-dimethyl-3-propylimidazolium iodide, 0.

N-nitration of secondary amines with 4-chloro-5-methoxy-2-nitropyridazin-3-one.

N-Nitration of 4-chloro-5-substituted-pyridazin-3-one with copper nitrate trihydrate in acetic anhydride gave the corresponding 4-chloro-2-nitro-5-substituted-pyridazin-3-one. 4-Chloro-5-alkoxy-2-nitropyridazin-3-ones such as 5-methoxy (2b) and 5-ethoxy (2d) derivatives showed excellent nitro group transfer potentiality. N-Nitration of some secondary amines with 2b gave the corresponding N-nitramines under mild neutral condition in good yields.

A one-pot synthesis of pyrido[2,3-b][1,4]oxazin-2-ones.

Pyrido[2,3-b][1,4]oxazin-2-ones are conveniently prepared in excellent yields by a one-pot annulation of N-substituted-2-chloroacetamides with 2-halo-3-hydroxypyridines with use of cesium carbonate in refluxing acetonitrile. The key transformation features a Smiles rearrangement of the initial O-alkylation product and subsequent cyclization.