Sleep deprivation predisposes allergic mice to neutrophilic lung inflammation.

Background: Although different studies associated sleep deprivation (SD) with systemic inflammatory changes, the effect of sleep duration on the pathology of allergic chronic diseases is poorly understood.

Objective: We sought to evaluate the influence of SD on allergen-induced pulmonary inflammation.

Methods: Ovalbumin (OVA)-sensitized C57BL/6 mice were exposed to a first set of intranasal OVA challenge under SD or healthy sleep (HS) conditions, followed by a second OVA challenge, 1 week apart.