[Bone and soft tissue Langerhans cell histiocytosis with multinucleated giant cells and BRAF V600E mutation].

Langerhans cell histiocytosis (LCH) is a heterogeneous disease characterized by proliferation of Langerhans cells and BRAF mutation in almost half of the cases. Bone involvement is common but large soft tissue disease is uncommon. We report a pediatric patient with a large tumor mass involving the left iliac bone and the adjacent soft tissue.

[Embryonic rhabdomyosarcoma of the prostate. Report of a case and review of the literature].

Objectives: To report a new case of prostatic rhabdomyosarcoma in a child.

Methods: Blood analysis, urinalysis, radiologic tests (abdominal ultrasound, intravenous urography, cystography, barium enema, lower extremities X-rays), and prostatic biopsy were performed.

Results/conclusions: Neoadjuvant treatment with chemotherapy and radiotherapy were started prior to intended radical prostatectomy, but the patient died before due to disease progression with dissemination.