Publications by authors named "Jesus Losada"
Article Synopsis
- Multinucleate cell angiohistiocytoma (MCAH) is a rare skin condition characterized by an unusual growth of fibrohistiocytic tissue in the dermis and increased blood vessel formation, but there is limited information on treatment options.* -
- This study reviews existing therapies for MCAH found in the literature and presents treatment outcomes for patients at one medical institution from 2010 to 2020, finding that 9 patients were treated with various methods including surgery, laser therapy, and vascular-targeted therapies.* -
- The findings suggest that pulsed dye laser (PDL) therapy is a preferred first-line treatment due to its effective and well-tolerated results, while surgical options may
Cardiotoxicity due to anthracyclines (CDA) affects cancer patients, but we cannot predict who may suffer from this complication. CDA is a complex disease whose polygenic component is mainly unidentified. We propose that levels of intermediate molecular phenotypes in the myocardium associated with histopathological damage could explain CDA susceptibility; so that variants of genes encoding these intermediate molecular phenotypes could identify patients susceptible to this complication.
View Article and Find Full Text PDFSFKs are involved in tumorigenesis and metastasis. Here we analyzed c-Src contribution to initial steps of metastasis by tetracycline-dependent expression of a specific shRNA-c-Src, which suppressed c-Src mRNA and protein levels in metastatic MDA-MB-231 cells. c-Src suppression did not alter cell proliferation or survival, but it significantly reduced anchorage-independent growth.
View Article and Find Full Text PDFGenetic abnormalities and clinical outcome in chronic lymphocytic leukemia.
Cancer Genet Cytogenet
November 2006
B-cell chronic lymphocytic leukemia (B-CLL) is the most common leukemia in the elderly population. Under conventional cytogenetic (CC) analysis, approximately 50% of CLL cases show clonal aberrations. Using fluorescent in situ hybridization (FISH), the percentage of patients with abnormalities rises to almost 80%, the most frequent being 13q14, ATM, and TP53 deletions and trisomy 12.
View Article and Find Full Text PDFBackground: Erythroplasia of Queyrat is an uncommon carcinoma in situ that usually arises on the mucosa of the glans penis or prepuce as red, shiny, sharply demarcated velvety plaques. The treatment is often difficult and associated with significant recurrence rates, especially in cases with urethral involvement.
Objective: To evaluate carbon dioxide laser treatment in a case of erythroplasia of Queyrat with urethral involvement.