Publications by authors named "Jesus E Sanchez-Garavito"
Article Synopsis
- * A new CAR called MC9999 was developed to target both tumor and immunosuppressive cells effectively, demonstrating consistent antitumor effects in models of breast cancer, lung cancer, melanoma, and glioblastoma multiforme (GBM).
- * MC9999 CAR T cells have shown the ability to cross the blood-brain barrier and specifically kill immunosuppressive cells within GBM tumors, highlighting their potential as a foundation for improved CAR
Purpose: Awake craniotomy (AC) is a procedure often performed concomitantly with direct electrical cortical stimulation (DES) and electrocorticography (ECoG) during functional brain mapping. Patients undergoing AC are at risk of acute symptomatic seizures, including intraoperative (IS) and early postoperative seizures (EPS) which can lead to higher risk of morbidity. Predicting those who are at risk of IS and EPS could alert clinicians and provide the ability to closely monitor and consider management changes in the acute setting to prevent seizures.
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- Awake minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) is a safe and effective technique that reduces tissue damage and costs for patients undergoing single-level spine surgery.
- A study reviewed cases from 2020 to 2023, finding that 16 patients, primarily older adults with common comorbidities, successfully underwent multilevel MIS-TLIF procedures with manageable complications and no new neurological deficits.
- The results suggest that despite the complexity of multilevel surgeries, this approach yields positive outcomes, including a short hospital stay and effective pain management, making it viable even for challenging cases.
Introduction: Advances in endoscopic endonasal transsphenoidal surgery have led to improved postoperative outcomes after pituitary adenoma resection, including reduced length of stay, complications and readmission rates, without compromising safety and satisfaction.
Methods: Our team implemented a perioperative protocol in January 2021 for patients undergoing endoscopic, transsphenoidal pituitary surgery. This study compares preoperative characteristics and postoperative outcomes in 279 patients between 2016 and 2022 (128 preprotocol and 151 postprotocol).
Objective: Traditionally, resection of nondominant hemisphere brain tumors was performed under general anesthesia. An improved understanding of right-lateralized neural networks has led to a paradigm shift in recent decades, where the right or nondominant hemisphere is no longer perceived as "functionally silent." There is an increasing interest in awake brain mapping for nondominant hemisphere resections.
View Article and Find Full Text PDFBackground And Objectives: Epilepsy is considered one of the most prevalent and severe chronic neurological disorders worldwide. Our study aims to analyze the national trends in different treatment modalities for individuals with drug-resistant epilepsy and investigate the outcomes associated with these procedural trends in the United States.
Methods: Using the National Inpatient Sample database from 2010 to 2020, patients with drug-resistant focal epilepsy who underwent laser interstitial thermal therapy (LITT), open surgical resection, vagus nerve stimulation (VNS), or responsive neurostimulation (RNS) were identified.
Introduction: In July 2017, a policy to increase the use of segmental grafts (SGs) was implemented at our institution. The aim was to compare changes in waitlist activity after implementation of this policy.
Methods: A single-center, retrospective study.
Article Synopsis
- The study analyzed the impact of having multiple meningiomas (MMs) on progression-free survival (PFS) in patients with WHO grade I meningiomas by reviewing patient records from 2009 to 2020.
- Results indicated that patients with multiple lesions had significantly shorter PFS and time to second intervention (TTSI) compared to those with a single lesion.
- Additionally, the analysis found that having more meningiomas negatively affected PFS and TTSI, with notable differences in outcomes based on race, where African American patients showed poorer PFS compared to non-Hispanic White patients.
Liver resection for metastatic cancer has become the standard of care for specific groups of patients, including noncolorectal non-neuroendocrine liver metastases (NCNNELM). Liver metastasis from differentiated thyroid carcinoma is considered rare, with an approximated frequency of 0.5%.
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