Publications by authors named "Jesus Delgado-de la Mora"

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasm of the digestive tract. Despite multiple therapeutic advances, patients with advanced disease frequently develop resistance to tyrosine kinase inhibitors (TKIs), and therefore represent a therapeutic challenge. We employed whole genome sequencing (WGS) on three metastatic GISTs refractory to various TKIs and explored a publicly available cohort of 499 GISTs.

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  • * Key mutations were identified in various genes, such as APC and TP53, with significant genomic alterations including a unique RAD51 biallelic deleterious translocation linked to homologous recombination deficiency.
  • * The research also found no major differences in mutation load or genetic features between traditional and oncocytic ACC subtypes, revealing a broad range of genomic changes that may help guide future cancer treatment options.
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  • The study aimed to assess if the amount of IgG4+ plasma cells in biopsies affects clinical and serological outcomes in patients with IgG4-related disease (IgG4-RD).
  • It included 57 patients and recorded various clinical and histological data, revealing that higher counts of IgG4+ plasma cells are linked to certain disease phenotypes and better clinical outcomes.
  • A count of 100 or more IgG4+ plasma cells per high-power field was associated with fewer relapses and a higher chance of remission, indicating its potential as a useful diagnostic indicator.
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Indolent clonal T-cell lymphoproliferative disorder (iCTLD-GI)/indolent T-cell lymphoma of the gastrointestinal tract (iTLP-GI) poses diagnostic challenges, and despite its rarity, accurate diagnosis is crucial for appropriate management. We report the case of 34-year-old female with a 19-year history of gastrointestinal symptoms suggestive of inflammatory bowel disease (IBD). Subsequent evaluation revealed iCTLD-GI/iTLP-GI with extensive Crohn's disease-like morphological alterations, previously unreported.

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We present an intriguing case involving a rare occurrence of sclerosing angiomatoid nodular transformation (SANT) in a 57-year-old woman with a history of granulomatosis with polyangiitis (GPA). Despite the extensive literature on SANT, its pathogenesis remains elusive. The patient, diagnosed with serum anti-proteinase 3 antineutrophil cytoplasmic antibody (PR3-ANCA)-positive GPA seven years earlier, exhibited a splenic lesion during imaging, leading to laparoscopic splenectomy due to severe abdominal pain.

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Background: Iron overload is frequent in patients with chronic liver disease, associated with shorter survival after liver transplantation in patients with hereditary hemochromatosis. Its effect on patients without hereditary hemochromatosis is unclear. The aim of the study was to study the clinical impact of iron overload in patients who underwent liver transplantation at an academic tertiary referral center.

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  • The 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria (2019 AECC) for IgG4-related disease (IgG4-RD) is a promising development, but previous studies primarily focused on White and Asian populations, highlighting the need for research in Latin America.
  • A study collected medical records from 300 patients across multiple Latin American countries, finding that 66.7% of IgG4-RD cases were accurately identified by the 2019 AECC, with specificity reaching 100%.
  • Although the criteria were effective in identifying true cases, the presence of other autoimmune diseases and certain autoantibodies limited its sensitivity, suggesting the criteria may exclude some patients who actually
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In people living with HIV, Kaposi Sarcoma (KS), a vascular neoplasm caused by KS herpesvirus (KSHV/HHV-8), remains one of the most common malignancies worldwide. Individuals living with HIV, receiving otherwise effective antiretroviral therapy, may present with extensive disease requiring chemotherapy. Hence, new therapeutic approaches are needed.

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  • Several reports have documented a rare primary liver tumor that exhibits features similar to follicular thyroid neoplasms, but it has unique characteristics, including specific genetic fusions and immunoreactivity for inhibin.
  • This study presents a comprehensive analysis of 11 cases of these tumors, highlighting the typical patient profile (adult women with no prior liver disease), tumor characteristics, and the methods used for investigation, such as whole-genome sequencing (WGS).
  • The findings indicate that these tumors, which show distinct growth patterns and genetic fusions, should be classified as "NIPBL:NACC1 fusion hepatic carcinoma," due to their unique histological and molecular features.
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Rosai-Dorfman disease is characterized by dilated lymph node sinuses filled with lymphocytes, plasma cells, and histiocytes. Many of these histiocytes classically exhibit emperipolesis of lymphocytes and plasma cells. Abundant immunoglobulin G4+ plasma cells occur in some cases, and a potential relationship with immunoglobulin G4-related disease has been suggested.

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The group encompasses at least 12 validated species of Palearctic and Afrotropical hard ticks, which are relevant in veterinary medicine and public health. The taxonomy of s.s.

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Introduction: Clinical distinction between arbovirus infections and those caused by rickettsia is crucial to initiate appropriate medical treatment.

Objective: To compare the differences between Rocky Mountain spotted fever (RMSF) and other vector-borne diseases (dengue and chikungunya) with similar clinical presentation, and to identify data that could aid rapid diagnosis of these diseases.

Methods: We evaluated sociodemographic, clinical and laboratory data of 399 patients from five hospitals and clinics of Sonora, Mexico, between 2004 and 2016, with laboratory-confirmed diagnosis of RMSF, dengue, or chikungunya.

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The Case A previously healthy woman, aged 32 years, presented to the oncology clinic with a 6-month history of left-breast tumor, mastalgia, and swollen axillary nodes. Physical examination was relevant for a 6-cm palpable mass in the upper outer quadrant of the left breast and an ipsilateral 2-cm, nonfixed axillary lymph node. Mammography showed a 1-cm mass in the upper outer quadrant, a 5.

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The genus Rickettsia encompasses 35 valid species of intracellular, coccobacilli bacteria that can infect several eukaryotic taxa, causing multiple emerging and re-emerging diseases worldwide. This work aimed to gather and summarise the current knowledge about the genus Rickettsia in Mexico, updating the taxonomy of the bacteria and their hosts by including all the records available until 2020, to elucidate host-parasite relationships and determine the geographical distribution of each Rickettsia species present in the country. Until now, 14 species of Rickettsia belonging to four groups have been recorded in Mexico.

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Background: Myelophthisis (MPT) has been associated with a dreadful prognosis. Patients' access to palliative care (PC) and factors influencing its clinical outcomes are poorly described. Our aim was to analyze the impact of patient- and disease-specific characteristics on survival of patients with MPT and describe their use of PC in a resource-limited setting.

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Background: Rocky Mountain spotted fever (RMSF) is a significant public health problem in Sonora, Mexico, resulting in thousands of cases and hundreds of deaths. Outbreaks of RMSF are perpetuated by heavy brown dog tick infestations in and around homes. During 2009-2015, there were 61 RMSF cases and 23 deaths in a single community of Sonora (Community A).

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