Publications by authors named "Jesus Alonso Valenzuela Perez"
We searched for the prevalence of actionable somatic mutations in exon 2 of the gene in western Mexican patients with CRC. Tumor tissue DNA samples from 150 patients with sporadic CRC recruited at the Civil Hospital of Guadalajara were analyzed. Mutations in exon 2 of the gene were identified using Sanger sequencing, and the data were analyzed considering clinical-pathological characteristics.
View Article and Find Full Text PDFSafety of Allogeneic Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Complex Perianal Fistulas Not Associated With Crohn's Disease: A Phase I Clinical Trial.
Dis Colon Rectum
March 2021
Background: Anal fistula treatment aims to eradicate the fistula, preserve the sphincter, prevent recurrence, and allow an early return to daily activities for the patient. Because of the difficulty of achieving these goals, stem cell-based therapy has emerged for the treatment of complex perianal fistula with promising results.
Objective: The objective of this study was to evaluate the safety of allogeneic mesenchymal stem cells in the treatment of complex anal fistula in patients without Crohn's disease.
Prevalence of the p.v600e variant in patients with colorectal cancer from Mexico and its estimated frequency in Latin American and Caribbean populations.
J Investig Med
June 2020
Article Synopsis
- The study examined the occurrence of the BRAF p.V600E mutation in colorectal cancer (CRC) patients from Western Mexico and compared it to rates in other Latin American and Caribbean countries.
- In a sample of 101 CRC patients, the mutation was found in 4% of them, and no significant difference was noted in variant detection when compared to other populations, except for Chile.
- The findings suggest that age and genetic background might influence the variation in p.V600E frequency across different populations, with an overall prevalence of 7.8% for Latin America and the Caribbean.
Introduction: Gallstone ileus can be a lethal disease, rarely suspected in the clinical scenario. It represents about 25% of all bowel obstruction cases in patients older than 65. There is a classification of gallstone ileus based on the onset time: acute, subacute and chronic (Karewsky syndrome).
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