Publications by authors named "Jesus A Gonzalo-Asensio"
The interplay between Fur (ferric uptake regulator) proteins and small, non-coding RNAs has been described as a key regulatory loop in several bacteria. In the filamentous cyanobacterium Anabaena sp. PCC 7120, a large dicistronic transcript encoding the putative membrane protein Alr1690 and an α-furA RNA is involved in the modulation of the global regulator FurA.
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- * Researchers created a high-throughput assay to analyze over 11,000 mutant strains of M. tuberculosis, using fluorescent staining and automated confocal microscopy to track their behavior within cells.
- * They identified ten key mutants that struggle with phagosomal maturation, uncovering disruptions in genes related to cell structure and lipid biosynthesis, specifically involving acyltrehalose-containing glycolipids, which are vital for the bacterium's survival in early infection stages.
Live tuberculosis vaccines based on phoP mutants: a step towards clinical trials.
Expert Opin Biol Ther
February 2008
Bacillus Calmette-Guérin (BCG) is the only preventive treatment for tuberculosis in humans, but this live vaccine confers variable protection against pulmonary tuberculosis in adults. Advances in the understanding of Mycobacterium tuberculosis immunopathogenesis have renewed hopes of developing new prophylactic vaccines conferring better protection than BCG. The authors describe here state-of-the-art attenuated live vaccines based on inactivation of the phoP gene, a transcriptional regulator of key virulence networks in M.
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