Progressive multifocal leukoencephalopathy in idiopathic CD4 lymphocytopenia: A case report and review of literature.

Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease due to a lytic infection of oligodendrocytes caused by polyoma virus (JC virus) infection. PML usually occurs in a setting of severe immunosuppression and is most commonly associated with human immunodeficiency virus (HIV) infection. Idiopathic CD4 lymphocytopenia is a very rare cause of PML and only a few cases have been reported in the literature.