Computer-Assisted Discovery of Alkaloids with Schistosomicidal Activity.

Schistosomiasis is a chronic parasitic disease caused by trematodes of the genus ; it is commonly caused by , which is transmitted by snails. Studies show that more than 200 million people are infected and that more than 90% of them live in Africa. Treatment with praziquantel has the best cost-benefit result on the market.

Orofacial antinociceptive activity and anchorage molecular mechanism in silico of geraniol.

We aimed to evaluate the orofacial antinociceptive effect of geraniol in mice and its molecular anchorage mechanism. Seven mice per group (probabilistic sample) were treated with geraniol (12.5, 25 and 50 mg/kg, i.

Computational Studies Applied to Flavonoids against Alzheimer's and Parkinson's Diseases.

Neurodegenerative diseases, such as Parkinson's and Alzheimer's, are understood as occurring through genetic, cellular, and multifactor pathophysiological mechanisms. Several natural products such as flavonoids have been reported in the literature for having the capacity to cross the blood-brain barrier and slow the progression of such diseases. The present article reports on enzymatic target studies and natural products as inhibitors for the treatment of Parkinson's and Alzheimer's diseases.