Publications by authors named "Jessie Jiang"
Prevalence of concha bullosa in a pediatric population.
Int J Pediatr Otorhinolaryngol
November 2024
Article Synopsis
- The study investigates the prevalence of concha bullosa (CB), a variation in nasal anatomy, in children using CT scans, as existing research is limited.
- Out of 695 children analyzed, 384 were included in the study, revealing that 39.8% had CB, with a higher prevalence in children over 4 years old.
- The most common type of CB was lamellar, and there was a noted association between CB and congenital nasal septal deviation, indicating that as the severity of CB increases, so does the severity of septal deviation.
Background: It has previously been demonstrated that Thrombelastography(TEG) angle may be associated with recurrence and survival in pancreas cancer in a cohort of patients operated on at the University of Colorado in 2016-2017. Now approaching 10 years of follow-up, we revisit these associations and strengthen these claims with multivariate analysis.
Methods: Retrospective chart review was performed.
Background: There is limited literature guiding the prescribing of direct oral anticoagulants (DOACs) early after cardiac surgery as this population has been excluded from landmark randomized controlled trials. This study aims to determine the rate of in-hospital DOAC use compared with warfarin early after cardiac surgery, evaluate factors associated with DOAC use, determine difference in postoperative length of stay, and characterize bleeding events.
Methods: A retrospective cohort study was conducted in adult patients with indications for anticoagulation and receiving either a DOAC or warfarin after cardiac surgery during their index hospitalization.
Aim/objective Neurological Pupil Index (NPi), measured by automated pupillometry (AP), allows the objective assessment of pupillary light reflex (PLR). NPi ranges from 0 (non-reactive) to 5 (normal). In this study, we aimed to compare neurologic and functional outcomes in children admitted for neurologic injury with normal (≥3) versus abnormal (<3) NPi measured during their pediatric intensive care unit (PICU) stay.
View Article and Find Full Text PDFBackground: Given altered pharmacokinetics in people with cystic fibrosis (pwCF), there is debate regarding optimal strategies for therapeutic drug monitoring (TDM) for aminoglycosides and vancomycin administered intravenously.
Objectives: To determine the TDM strategy for IV aminoglycosides and IV vancomycin associated with optimal clinical outcomes in pwCF.
Data Sources: Several databases (MEDLINE, Embase, CINAHL, Web of Science, Cochrane Central Register of Controlled Trials, and ClinicalTrials.
Article Synopsis
- The study investigates the effectiveness of tissue plasminogen activator (tPA) combined with thrombelastography (TEG) to predict massive transfusion (MT) in trauma patients with hypotension.
- It analyzes trauma activation patients with early or delayed hypotension, comparing tPA-challenge-TEG's predictive performance to existing strategies using receiver operating characteristics curves.
- Results show that tPA-challenge-TEG is the best predictor of MT for early hypotension cases and performs well in delayed hypotension cases, offering insights for early MT recognition.
SBMLDiagrams: a python package to process and visualize SBML layout and render.
Bioinformatics
January 2023
Article Synopsis
- SBML (Systems Biology Markup Language) is a standard format for sharing biochemical models, and the SBML Layout and Render package helps create pathway diagrams for these models.
- The new Python package SBMLDiagrams simplifies adding and retrieving layout information through an easy-to-use API and supports diagram rendering to formats like PNG and PDF.
- SBMLDiagrams is open-source under the MIT license, available for major platforms, and can be installed via pip from GitHub.
Article Synopsis
- Persistent ascites (PA) after liver transplant (LT) is a common issue that is linked to platelet count and function.
- A study of 105 LT recipients found that 28% experienced PA, with factors like platelet transfusions and low clot strength contributing to this condition.
- Patients with PA not only stayed longer in the hospital but also had a higher likelihood of suffering from intraabdominal infections.
The relationship between stress and disease onset and relapse in multiple sclerosis: A systematic review.
Mult Scler Relat Disord
November 2022
Background: The impact of stress in persons with multiple sclerosis (MS) is an area of ongoing inquiry. A limited number of published systematic reviews have reported an association between stress and MS onset. In addition to reviewing more recently published evidence, this review expands upon existing systematic reviews by considering the timing of stress exposure (childhood or adulthood).
View Article and Find Full Text PDFBackground: Infection is a leading cause of morbidity in liver transplant (LT). Considering that the fibrinolytic system is altered in sepsis, we investigated the relationship between fibrinolysis resistance (FR) and post-transplant infection.
Methods: Fibrinolysis was quantified using thrombelastography (TEG) with the addition of tPA to quantify FR.
Article Synopsis
- 8-Oxo-7,8-dihydroguanine (8-oxoG) is a significant RNA modification linked to health issues like cancer and aging, caused by oxidative stresses.
- Researchers identified four proteins in the extremophile bacterium Deinococcus radiodurans that preferentially bind to 8-oxoG-modified RNA, with PNPase and RhlB showing the strongest interactions.
- Deleting these proteins made D. radiodurans more sensitive to oxidative stress and highlighted their roles in managing oxidative RNA damage while not affecting oxidized DNA.
The generation of neural stem and progenitor cells following injury is critical for the function of the central nervous system, but the molecular mechanisms modulating this response remain largely unknown. We have previously identified the G protein-coupled receptor 37 (GPR37) as a modulator of ischemic damage in a mouse model of stroke. Here we demonstrate that GPR37 functions as a critical negative regulator of progenitor cell dynamics and gliosis following ischemic injury.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the role of the Signal Recognition Particle (SRP) in the transport of proteins involved in oxidative stress resistance in a specific bacterium.
- The knockdown of SRP RNA significantly decreased bacterial survival against hydrogen peroxide and ionizing radiation, highlighting its importance in stress response.
- Proteomic analysis revealed that many proteins crucial for oxidative stress management were poorly localized in SRP-deficient strains, indicating that SRP is essential for transporting antioxidant proteins to where they are needed.
Article Synopsis
- Nonribosomal peptide synthetases (NRPSs) make unique chemical products by adding special parts called tailoring domains.
- A specific type of these enzymes, called linear gramicidin synthetase, starts with a special formylation domain that may have come from a sugar-related gene.
- Scientists studied a sugar formyltransferase (FT) from Anoxybacillus kamchatkensis and found out how it creates a new compound, using advanced techniques like gene analysis and X-ray crystallography to understand how this enzyme has changed over time to work as part of NRPS.