Publications by authors named "Jessica Z Lacerda"
Melatonin, a hormone secreted by pineal gland, exerts antimetastatic effects by reducing tumor cell proliferation, migration and invasion. MicroRNAs (miRNAs) are small, non-coding RNAs that play a crucial role in regulation of gene expression and biological processes of the cells. Herein, we search for a link between the tumor/metastatic-suppressive actions of melatonin and miRNA expression in triple-negative breast cancer cells.
View Article and Find Full Text PDFBackground: The high mortality rate of breast cancer is related to the occurrence of metastasis, a process that is promoted by tumor angiogenesis. MicroRNAs are small molecules of noncoding mRNA that play a key role in gene regulation and are directly involved in the progression and angiogenesis of various tumor types, including breast cancer. Several miRNAs have been described as promoters or suppressors angiogenesis and may be associated with tumor growth and metastasis.
View Article and Find Full Text PDFBreast cancer progression is composed of multiple steps that are influenced by tumor cell adaptations to survive under acidic conditions in the tumor microenvironment. Regulation of this cell survival behavior is a promising strategy to avoid cancer development. Melatonin is a natural hormone produced and secreted by the pineal gland capable of modulating different biological pathways in cancer.
View Article and Find Full Text PDFArticle Synopsis
- - The success of skin grafts relies on reducing local inflammation and promoting new blood vessel formation, with the N-terminal portion of Annexin A1 (AnxA1) showing promise due to its anti-inflammatory effects.
- - A study investigated the impact of the AnxA1 peptide Ac2-26 on skin grafts in mice, finding that it improved graft acceptance, increased blood vessel formation, and enhanced the levels of key growth factors while balancing inflammatory cytokines.
- - AnxA1 treatment also promoted better migration and proliferation of human endothelial cells, supporting the idea that it facilitates tissue regeneration after skin grafting by managing inflammation and enhancing angiogenesis.
Aims: Breast cancer represents the second most prevalent tumor-related cause of death among women. Although studies have already been published regarding the association between breast tumors and miRNAs, this field remains unclear. MicroRNAs (miRNAs) are defined as non-coding RNA molecules, and are known to be involved in cell pathways through the regulation of gene expression.
View Article and Find Full Text PDFBackground: Cancer-associated fibroblast (CAFs) are the most abundant cells in the tumor microenvironment, able to secrete growth factors and act on tumor progression. Melatonin is associated with several mechanisms of action with oncostatics and oncoprotectors effects, and also participate in the reduction of synthesis of surrounding fibroblasts and endothelial cells in breast cancer.
Objective: The objectives of this study were to determine the effectiveness of melatonin in cell viability and expression of proteins involved in angiogenesis and inflammation in triplenegative mammary tumor cell line (MDA-MB-231) and in co-culture with CAFs.