Publications by authors named "Jessica Woodward"
Article Synopsis
- Chromosomal instability is a key feature of cancer, but mutations in mitotic regulators like condensin complexes, which help separate chromosomes during cell division, are often overlooked.
- Research shows that mice with mutations in a specific condensin II subunit (Caph2) develop T-cell lymphoma, indicating a link between condensin dysfunction and cancer development.
- The study reveals that the Caph2 mutation disrupts ploidy maintenance in T cells, leading to DNA damage and increased ploidy, with additional findings suggesting that tumor suppressor gene deletions and P53 inactivation further contribute to more aggressive cancers.
Novel antiviral host factor, TNK1, regulates IFN signaling through serine phosphorylation of STAT1.
Proc Natl Acad Sci U S A
February 2014
In response to viral infection, the host induces over 300 IFN-stimulated genes (ISGs), which are the central component of intracellular antiviral innate immunity. Inefficient induction of ISGs contributes to poor control and persistence of hepatitis C virus infection. Therefore, further understanding of the hepatocytic ISG regulation machinery will guide us to an improved management strategy against hepatitis C virus infection.
View Article and Find Full Text PDFUnlabelled: Type 1 interferon (IFN) continues to be the foundation for the current standard of care combination therapy for chronic hepatitis C virus (HCV) infection, yet the component interferon-stimulated genes (ISGs) that mediate the antiviral actions of IFN are not fully defined. Interferon-induced transmembrane protein 1 (IFITM1) is an ISG product that suppresses early stage infection by a number of viruses through an unknown mechanism of action. Moreover, the actions of IFITM1 on HCV infection are not fully elucidated.
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