Publications by authors named "Jessica Valat"
One challenge faced by scientists from the alternative RNA splicing field is to decode the cooperative or antagonistic effects of splicing factors (SFs) to understand and eventually predict splicing outcomes on a genome-wide scale. In this manuscript, we introduce SplicingLore, an open-access database and web resource that help to fill this gap in a straightforward manner. The database contains a collection of RNA-sequencing-derived lists of alternative exons regulated by a total of 75 different SFs.
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- DDX5 and DDX17 are RNA helicases that play important roles in gene expression, particularly in regulating transcription and splicing, though their exact mechanisms are not fully known.
- Analysis of human cells lacking DDX5 and DDX17 showed significant disruptions in splicing and 3' end processing of RNA.
- The study suggests that DDX5 and DDX17 help form chromatin loops that connect specific gene regions to their promoters, influencing how RNA is spliced and processed.