Publications by authors named "Jessica V Assis"
Second booster dose improves antibody neutralization against BA.1, BA.5 and BQ.1.1 in individuals previously immunized with CoronaVac plus BNT162B2 booster protocol.
Front Cell Infect Microbiol
April 2024
Article Synopsis
- The study investigates the antibody response of individuals vaccinated with the CoronaVac vaccine plus additional booster doses against the Omicron variants BA.1, BA.5, and BQ.1.1.
- Serum samples from 160 vaccinated individuals were analyzed at three different time points (9, 12, and 18 months) to evaluate the effectiveness of the vaccination and boosters.
- Results showed that while a first booster improved neutralization against BA.1, the second booster significantly enhanced antibody levels against all subvariants, highlighting the importance of boosters in combating immunity evasion by Omicron variants.
The COVID-19 pandemic has caused a severe global health and economic crisis, with significant consequences for human mortality and morbidity. Therefore, there is an urgent need for more studies on the immune response to SARS-CoV-2 infection, both to enhance its effectiveness and prevent its deleterious effects. This study presents the chronology of antibodies during six months after infection in hospitalized patients and the kinetics of serum soluble mediators of the cellular response triggered by SARS-CoV-2.
View Article and Find Full Text PDFRapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.
Rev Soc Bras Med Trop
May 2023
Background: SARS-CoV-2 virus originated in Wuhan (China) in December (2019) and quickly spread worldwide. Antigen tests are rapid diagnostic tests (RDT) that produce results in 15-30 min and are an important tool for the scale-up of COVID-19 testing. COVID-19 diagnostic tests are authorized for self-testing at home in some countries, including Brazil.
View Article and Find Full Text PDFBackground: The emergence of the new SARS-CoV-2 Omicron variant, which is known to have a large number of mutations when compared to other variants, brought to light the concern about vaccine escape, especially from the neutralization by antibodies induced by vaccination.
Methods: Based on viral microneutralization assays, we evaluated in 90 individuals the impact on antibody neutralization induction, against Omicron variant, by a booster dose of BNT162b2 mRNA vaccine after the CoronaVac primary vaccination scheme.
Results: Here we show that the percentage of seroconverted individuals 30 and 60 days after CoronaVac scheme was 16.
The emergence of the new SARS-CoV-2 Omicron variant, which is known to accumulate a huge number of mutations when compared to other variants, brought to light the concern about vaccine escape, especially from the neutralization by antibodies induced by vaccination. In this scenario, we evaluated the impact on antibody neutralization induction, against Omicron variant, by a booster dose of BNT162b2 mRNA vaccine after the CoronaVac primary vaccination scheme. The percentage of seroconverted individuals 30 and 60 days after CoronaVac scheme was 17% and 10%, respectively.
View Article and Find Full Text PDFColorectal cancer (CRC) is a public health concern and the second most common type of cancer among men and women causing a significant mortality. Biomarkers closely linked to the disease morbidity could holds potential as diagnostic and/or prognostic biomarker for the disease. This review provides an overview of recent advances in the search for colorectal cancer biomarkers through genomics and proteomics according to clinical function and application.
View Article and Find Full Text PDFArticle Synopsis
- Accurate and rapid diagnosis is crucial for controlling schistosomiasis, as existing methods like POC-CCA perform poorly in low-endemicity areas.* -
- A new method called POC-CCA filter (FLT) was developed, incorporating a quick urine concentration step that significantly improved diagnostic accuracy in Brazilian endemic areas.* -
- Results showed that POC-CCA FLT had a much higher accuracy rate (up to 100%) compared to the traditional POC-CCA, enhancing its effectiveness in diagnosing cases both before and after treatment.*