Publications by authors named "Jessica Thornton"

Darker skin is underrepresented in medical textbooks. This may contribute to inequity in our system. We assessed skin color representation in infectious disease textbooks and compared diseases associated with social stigma to those not stigmatized.

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Background: In 2020, a multidose human-milk fortifier (MDHMF) was designed to improve the process of human-milk (HM) fortification. The bottle of MDHMF (5.5 oz, 163 ml) allows aseptic removal of HMF in a precise measure.

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Melanoma is one of the seven most common cancers in the United States, and its incidence is still increasing. Since 2011, developments in targeted therapies and immunotherapies have been essential for significantly improving overall survival rates. Prior to the advent of targeted and immunotherapies, metastatic melanoma was considered a death sentence, with less than 5% of patients surviving more than 5 years.

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Background: Symmetric dimethylarginine (SDMA) is a renal biomarker correlated with glomerular filtration rate (GFR).

Objectives: Describe changes in SDMA in clinically healthy foals and their mares during the first month postfoaling.

Animals: Convenience sampling of healthy periparturient Thoroughbred mares and their full-term foals from a population of client-owned horses.

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Article Synopsis
  • HIV-associated neurocognitive disorders (HANDs) are common among older people living with HIV in Tanzania, with a prevalence rate of 47% found in a study of 253 participants aged 50 and over who received combination antiretroviral therapy (cART).
  • The study identified various levels of cognitive impairment: 25% had asymptomatic neurocognitive impairment, 18% had mild neurocognitive disorder, and 3.6% were diagnosed with HIV-associated dementia.
  • A significant one-year incidence rate of 37.2% was reported, along with the observation that some cognitive impairments could be reversible, highlighting the need for further research into the causes and potential interventions for cognitive health in this population.
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Aims: The Performance Quality Rating Scale (PQRS) is an observational measure that captures performance at the level of activity and participation. Developed for use with the Cognitive Orientation to daily Occupational Performance (CO-OP), it is a highly individualized approach to measurement. CO-OP is currently being studied in childhood-onset hyperkinetic movement disorders (HMD) and deep brain stimulation.

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Validated screening tools for HIV-associated neurocognitive disorders (HAND) are lacking for the newly emergent ageing population of people living with HIV (PLWH) in sub-Saharan Africa (SSA). We aimed to validate and compare diagnostic accuracy of two cognitive screening tools, the International HIV dementia scale (IHDS), and the Identification and Interventions for Dementia in Elderly Africans (IDEA) screen, for identification of HAND in older PLWH in Tanzania. A systematic sample of 253 PLWH aged ≥ 50 attending a Government clinic in Tanzania were screened with the IHDS and IDEA.

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Article Synopsis
  • The study investigates risk factors for HIV-associated neurocognitive disorder (HAND) among individuals aged 50 and older in a Tanzanian HIV clinic, finding a significant prevalence of symptomatic HAND in this population.
  • Of 253 participants, 21.7% were identified with symptomatic HAND, with increased risk linked to living alone, being illiterate, and being older at the time of HIV diagnosis.
  • The findings suggest that factors like social isolation and lack of education may contribute to cognitive decline, while traditional HIV factors like CD4 count do not appear directly related to symptomatic HAND in this demographic.
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Background: Task shifting has been suggested as one way to help manage the increasing burden of dementia in sub-Saharan Africa (SSA). However, brief, easy-to-use and valid screening tools are needed to support this approach. Our team has developed an 11-item questionnaire to assess instrumental activities of daily living (IADLs) in SSA, the Identification and Intervention for Dementia in Elderly Africans (IDEA)-IADL questionnaire.

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