The role of serum chromogranin A in diarrhoea predominant irritable bowel syndrome.

Background & Aims: Elevated serum chromogranin A (CgA) levels have been reported co-incidentally in a small group of irritable bowel syndrome (IBS) patients (n=19). Our aim was to ascertain the prevalence of elevated CgA in diarrhoea predominant Rome II IBS (D-IBS) patients and investigate if this could be a marker for octreotide therapy.

Methods: Patients with Rome II D-IBS were recruited prospectively and investigated as per British Society Guidelines including serial CgA levels (u/l).