Clinical Predictors of Recurrence After Primary Clostridioides difficile Infection: A Prospective Cohort Study.

Background: Recurrent Clostridioides difficile infection (CDI) is a major public health threat. While clinical prediction tools exist, they do not incorporate the newest Infectious Diseases Society of America guidelines.

Methods: This was a prospective longitudinal study of patients experiencing their first episode of uncomplicated CDI.

Early Antibiotic Use After Fecal Microbiota Transplantation Increases Risk of Treatment Failure.

Antibiotic use within the first 8 weeks after fecal microbiota transplantation (FMT) may disrupt microbial engraftment and limit FMT effectiveness. We aimed to assess the burden of antibiotic use within 8 weeks of FMT and its impact on FMT efficacy.