Drug addicts often relapse due to memories linked to drug experiences, and therapies targeting memory reconsolidation could help break this cycle.
This study examines whether altering the endocannabinoid system affects the reconsolidation of memories associated with opioid use in rats.
Results indicate that blocking CB1 receptors impaired the reconsolidation of morphine-related memories, while activating cannabinoid receptors had little impact, although enhancing endocannabinoid signaling showed a temporary effect.