Publications by authors named "Jessica S Schuster"

The likely genetic architecture of complex diseases is that subgroups of patients share variants in genes in specific networks sufficient to express a shared phenotype. We combined high throughput sequencing with advanced bioinformatic approaches to identify such subgroups of patients with variants in shared networks. We performed targeted sequencing of patients with 2 or 3 generations of preterm birth on genes, gene sets and haplotype blocks that were highly associated with preterm birth.

View Article and Find Full Text PDF

Background: Runs of homozygosity (ROH) are consecutive homozygous genotypes, which may result from population inbreeding or consanguineous marriages. ROH enhance the expression of recessive traits.

Methods: We mapped ROH in a case control study of women delivering at term compared with women delivering at or before 34 wk gestation.

View Article and Find Full Text PDF