Sex differences in the subjective effects of oral Δ-THC in cannabis users.

Previous studies suggest that there are sex differences in endocannabinoid function and the response to exogenous cannabinoids, though data from clinical studies comparing acute cannabinoid effects in men and women under controlled laboratory conditions are limited. To further explore these potential differences, data from 30 cannabis users (N=18 M, 12 F) who completed previous Δ-tetrahydrocannabinol (Δ-THC) discrimination studies were combined for this retrospective analysis. In each study, subjects learned to discriminate between oral Δ-THC and placebo and then received a range of Δ-THC doses (0, 5, 15 and a "high" dose of either 25 or 30mg).