Publications by authors named "Jessica R McQuaid"
Article Synopsis
- - Cerebrovascular dysfunction following pediatric mild traumatic brain injury (pmTBI) is not well-studied compared to other injuries, but this study aimed to analyze cerebrovascular reactivity (CVR) and cerebral blood flow (CBF) in youths aged 8-18 post-injury.
- - Researchers collected data approximately one week and four months after the injury, observing subtle clinical and cognitive deficits at the one-week mark that improved over time for some but not all participants.
- - The study found increased CVR responses in pmTBI patients, particularly in certain brain regions, and noted that cerebrovascular dysfunction could persist for up to four months after the injury without a direct link to cognitive deficits or post-concussive
With the steadily increasing abundance of longitudinal neuroimaging studies with large sample sizes and multiple repeated measures, questions arise regarding the appropriate modeling of variance and covariance. The current study examined the influence of standard classes of variance-covariance structures in linear mixed effects (LME) modeling of fMRI data from patients with pediatric mild traumatic brain injury (pmTBI; N = 181) and healthy controls (N = 162). During two visits, participants performed a cognitive control fMRI paradigm that compared congruent and incongruent stimuli.
View Article and Find Full Text PDFInvestigation of neural mechanisms of real-time functional MRI neurofeedback (rtfMRI-nf) training requires an efficient study control approach. A common rtfMRI-nf study design involves an experimental group, receiving active rtfMRI-nf, and a control group, provided with sham rtfMRI-nf. We report the first study in which rtfMRI-nf procedure is controlled through counterbalancing training runs with active and sham rtfMRI-nf for each participant.
View Article and Find Full Text PDFResting-state fMRI can be used to identify recurrent oscillatory patterns of functional connectivity within the human brain, also known as dynamic brain states. Alterations in dynamic brain states are highly likely to occur following pediatric mild traumatic brain injury (pmTBI) due to the active developmental changes. The current study used resting-state fMRI to investigate dynamic brain states in 200 patients with pmTBI (ages 8-18 years, median = 14 years) at the subacute (∼1-week post-injury) and early chronic (∼ 4 months post-injury) stages, and in 179 age- and sex-matched healthy controls (HC).
View Article and Find Full Text PDFThere is a growing body of research showing that cerebral pathophysiological processes triggered by pediatric mild traumatic brain injury (pmTBI) may extend beyond the usual clinical recovery timeline. It is paramount to further unravel these processes, because the possible long-term cognitive effects resulting from ongoing secondary injury in the developing brain are not known. In the current fMRI study, neural processes related to cognitive control were studied in 181 patients with pmTBI at sub-acute (SA; ~1 week) and early chronic (EC; ~4 months) stages post-injury.
View Article and Find Full Text PDFArticle Synopsis
- The study examines how age and biological sex influence the reporting of persistent post-concussive symptoms (PCS) in children after mild traumatic brain injury (pmTBI), comparing reports from children and their parents.
- Findings indicate that healthy controls and their parents reported higher PCS levels retrospectively compared to assessments at later time points, with child-parent agreement peaking for female adolescents right after the injury.
- The study suggests that parents may have a cultural bias in rating symptoms, especially for females, and emphasizes that relying on child self-reports may be more accurate for assessing PCS than parental reports.