The Development and Pre-Clinical Anti-Inflammatory Efficacy of a New Transdermal Ureasil-Polyether Hybrid Matrix Loaded with Flavonoid-Rich Leaf Extract.

This study aimed to develop a novel ureasil-polyether transdermal hybrid matrix (U-PEO) loaded with concentrated extract (AMCE), which exhibits potent anti-inflammatory activity. The extract was obtained by maceration, a method that allowed for the extraction of a high concentration of flavonoids (39.27 mg/g of extract).

Cytotoxic CD4 T cells driven by T-cell intrinsic IL-18R/MyD88 signaling predominantly infiltrate -infected hearts.

Increasing attention has been directed to cytotoxic CD4 T cells (CD4CTLs) in different pathologies, both in humans and mice. The impact of CD4CTLs in immunity and the mechanisms controlling their generation, however, remain poorly understood. Here, we show that CD4CTLs abundantly differentiate during mouse infection with the intracellular parasite .

Lung injury caused by exposure to the gaseous fraction of exhaust from biomass combustion (cashew nut shells): a mice model.

Currently, to reduce the use of nonrenewable energy sources in energy matrices, some industries have already incorporated biomass as a source of energy for their processes. Additionally, filters are used in an attempt to retain the particulate matter present in exhaust gases. In this work, the emission gases of a cashew nut shell (CNS) combustion reactor and the deleterious effects on the respiratory system of mice exposed to gaseous fraction present in CNS emissions (GF-CNS) are analyzed.

New species of grasshopper genus Aptoceras Bruner, 1908 (Orthoptera, Acrididae, Ommatolampidinae, Ommtolampidiini) from Iguaçu National Park (Southern Brazil), including a taxonomic key and distribution data.

A new species of the Neotropical grasshopper genus Aptoceras Bruner, 1908 is described from individuals collected in the Iguaçu National Park, Paraná State, Brazil. Aptoceras iguassuensis n. sp.

Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report.

The authors report the first case of fatal septic shock, a rare clinical presentation of paracoccidioidomycosis (PCM) caused by Paracoccidioides brasiliensis S1. We also provide an immunological evaluation of the patient. Severe clinical signs such as organ dysfunction and digital gangrene occurred in this case.

Human neonates display altered ex vivo monokine production related to healthy adults.

The inflammatory response plays an important role during the induction of several neonatal diseases. Previous studies have shown that during newborn infections, the natural imbalance between pro- and anti-inflammatory responses shifts toward the production of pro-inflammatory cytokines. In this study, we employed an array system to detect 9 pro- and anti-inflammatory cytokines, and performed ELISA for 6 other cytokines.