Publications by authors named "Jessica R Lee"
Neurobiol Dis
November 2020
Article Synopsis
- - Rett syndrome (RTT) is a severe neurodevelopmental disorder primarily caused by mutations in the MECP2 gene, and genetic restoration in mouse models has shown promise in reversing symptoms, indicating potential for new therapies.
- - Current clinical trials for RTT need well-defined outcome measures and biomarkers, but there are no validated tools to predict disease prognosis or treatment responses specifically for RTT.
- - Researchers studied neurophysiological changes in a mouse model of RTT and found several alterations that correlate with disease severity, suggesting these changes could serve as potential non-invasive biomarkers for future preclinical and clinical trials.
