Publications by authors named "Jessica N Limberg"
Background: Axillary management after neoadjuvant chemotherapy (NAC) is evolving but axillary lymph node dissection (ALND) remains the standard of care for patients with residual nodal disease. The results of the Alliance A011202 trial evaluating the oncologic safety of ALND omission in this cohort are pending but we hypothesize that ALND omission is already increasing.
Methods: The National Cancer Database was queried to identify patients diagnosed with cT1-3N1M0 breast cancer who underwent NAC and had residual nodal disease (ypN1mi-2) from 2012 to 2021.
Article Synopsis
- Proliferative breast atypical lesions, like atypical ductal hyperplasia (ADH) and lobular intraepithelial neoplasms (LIN), increase the risk for developing ductal carcinoma in situ (DCIS) and invasive breast cancer (IBC), though the timing for progression varies widely.
- A study of 418 patients diagnosed with these lesions revealed that 17% developed either IBC or DCIS, with almost half of these cases occurring within 5 years after the initial diagnosis.
- Neither patient demographics nor clinical features were linked to the timing or likelihood of developing subsequent cancer events, indicating that atypia is a significant marker for overall malignancy risk.
Background: When needle core biopsies (NCBs) of the breast reveal radial scar or complex sclerosing lesions (RSLs), excision is often recommended despite a low risk of malignancy in the modern era. The optimal management of NCBs revealing RSLs is controversial, and understanding of the natural history of unresected RSLs is limited.
Methods: We retrospectively analyzed pathology and imaging data from 148 patients with NCB revealing RSL without atypia from 2015 to 2019 to determine the prevalence of malignancy and the behavior of RSLs undergoing active surveillance (AS).
Objective: To quantify the contribution of key steps in antireflux surgery on compliance of the EGJ.
Background: The lower esophageal sphincter and crural diaphragm constitute the intrinsic and extrinsic sphincters of the EGJ, respectively. Interventions to treat reflux attempt to restore the integrity of the EGJ.
Background: The incidence of papillary thyroid microcarcinoma (PTMC) has increased over the past decade. The American Thyroid Association (ATA) suggests that these patients may undergo either thyroid lobectomy or active surveillance. It remains unclear whether there exists a subgroup of PTMC patients who may benefit from more aggressive treatment due to increased risk of recurrence.
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