The Impact of Nonpharmacological Interventions on Patient Experience, Opioid Use, and Health Care Utilization in Adult Cardiac Surgery Patients: Protocol for a Mixed Methods Study.

Background: Despite pharmacological treatments, patients undergoing cardiac surgery experience severe anxiety and pain, which adversely affect outcomes. Previous work examining pediatric and nonsurgical adult patients has documented the effectiveness of inexpensive, nonpharmacological techniques to reduce anxiety and pain as well as health care costs and length of hospitalization. However, the impact of nonpharmacological interventions administered by a dedicated comfort coach has not been evaluated in an adult surgical setting.

The clinical impact and incidence of periocular pigmentation associated with either latanoprost or bimatoprost therapy.

Purpose: To evaluate the incidence and characteristics of periocular pigmentation with latanoprost versus bimatoprost.

Methods: A retrospective, active-controlled comparison of consecutive patients treated with latanoprost or bimatoprost for 12 months evaluating patients to determine the incidence, characteristics, and reversibility of periocular pigmentation.

Results: Periocular pigmentation was found in 1% patients treated with latanoprost and 6% patients treated with bimatoprost within 12 months of beginning treatment (p = 0.

Efficacy and safety of latanoprost versus travoprost in exfoliative glaucoma patients.

Objective: To evaluate 24-hour intraocular pressure (IOP) efficacy of latanoprost versus travoprost, each given every evening, in exfoliative glaucoma patients.

Design: Prospective, observer-masked, crossover comparison.

Participants: Forty patients with exfoliation glaucoma.

24-Hour control with a latanoprost-timolol fixed combination vs timolol alone.

Objective: To evaluate 24-hour intraocular pressure (IOP) control with an evening-dosed latanoprost-timolol maleate fixed combination vs timolol alone in patients with primary open-angle glaucoma.

Methods: After a medicine-free period, qualified patients were randomized to either placebo dosed in the morning with a latanoprost-timolol fixed combination dosed in the evening or timolol alone dosed twice daily for 8 weeks. Patients were then switched to the opposite treatment for 8 weeks.

24-hour intraocular pressure control with maximum medical therapy compared with surgery in patients with advanced open-angle glaucoma.

Purpose: The purpose of this study was to evaluate 24-hour intraocular pressure (IOP) control in patients with moderate to severe open-angle glaucoma treated by trabeculectomy and mitomycin C versus maximum tolerated medical therapy.

Design: Prospective observational study.

Participants: Thirty surgical patients and 30 medically treated patients with advanced glaucoma.

24-hour intraocular pressure control obtained with evening- versus morning-dosed travoprost in primary open-angle glaucoma.

Purpose: To evaluate the quality of 24-hour intraocular pressure (IOP) control between morning- and evening-dosed travoprost in primary open-angle glaucoma patients.

Design: Prospective, crossover, double-masked comparison.

Methods: After a 6-week medicine-free period, 33 patients were randomized to receive travoprost dosed in the morning or evening.

Mean intraocular pressure and progression based on corneal thickness in primary open-angle glaucoma.

Purpose: The aim of this study was to evaluate the association of corneal thickness on the incidence of glaucomatous progression at individual levels of intraocular pressure.

Methods: A retrospective, noninterventional evaluation of patients with primary open-angle glaucoma who were either stable over 5 years or had glaucomatous progression before 5 years of follow-up was performed. Each patient had central thickness corneal measurements documented.

Twenty-four-hour control with latanoprost-timolol-fixed combination therapy vs latanoprost therapy.

Objective: To evaluate the 24-hour efficacy and safety of the latanoprost-timolol maleate-fixed combination vs latanoprost therapy in patients with primary open-angle glaucoma.

Methods: A prospective, observer-masked, crossover, active-controlled, randomized comparison in which after a 6-week medicine-free period, patients were randomized to either latanoprost-timolol-fixed combination therapy or latanoprost therapy, both dosed once each evening, alone for 8 weeks. Patients were then switched to the opposite treatment for 8 weeks.

Latanoprost 0.005% versus bimatoprost 0.03% in primary open-angle glaucoma patients.

Objective: To evaluate latanoprost versus bimatoprost given each evening over the 24-hour diurnal curve.

Design: Double-masked, 2-center, crossover comparison.

Participants: Forty-two of 44 patients with primary open-angle glaucoma (POAG) completed the study.

A persistency and economic analysis of latanoprost, bimatoprost, or beta-blockers in patients with open-angle glaucoma or ocular hypertension.

Purpose: The aim of this study was to evaluate differences in the persistency and treatment costs for latanoprost, bimatoprost, or beta-blockers in open-angle glaucoma or ocular hypertensive patients.

Methods: This study was a retrospective, multicenter, parallel, active-controlled comparison of patients who were prescribed with ocular hypotensive monotherapy between September 1996 and August 2002.

Results: 1,182 patients were included.

Dropout rates for intent-to-treat and per protocol analyses.

Purpose: To describe dropout rates for the intent-to-treat and per protocol analyses from prospective clinical trials.

Methods: Review of prospective multi-center parallel studies of 100 patients or more from 1996 onwards.

Results: We identified 33 articles (70 treatment arms) that fit the criteria for this study.

Can patients guess their intraocular pressure?

Purpose: To determine whether patients can guess their intraocular pressure (IOP).

Design: Patient survey.

Methods: We asked consecutive patients to guess their IOP and then indicate the IOP and the symptoms that allowed them to guess.

Factors associated with long-term progression or stability in exfoliation glaucoma.

Objective: To evaluate the effect of intraocular pressure (IOP) reduction on long-term progression or stability in patients with exfoliation glaucoma.

Design: Multicenter (Greece, Spain, Russia, and Hungary), retrospective analysis.

Methods: Medical record analysis of 167 patients with at least 5 years of follow-up, who were stable (n = 85) or whose condition had progressed (n = 82) after the beginning of the follow-up period.

Corneal punctate staining with latanoprost, bimatoprost, and travoprost in healthy subjects.

Purpose: To evaluate short-term conjunctival and corneal punctate staining with latanoprost, bimatoprost, and travoprost in healthy individuals.

Materials And Methods: A single centered, active-controlled, three-period crossover comparison that evaluated conjunctival and corneal punctate staining, by grade and individual stains, in healthy subjects after dosing for five days in one eye with latanoprost, bimatoprost, or travoprost. Staining was evaluated at 24-hour trough (Hour 0) and at Hour 1 after dosing.