Proposition of Pharmacophore Models for Malaria: A Review.

In the field of medicinal chemistry, the concept of pharmacophore refers to the specific region of a molecule that possesses essential structural and chemical characteristics for binding to a receptor and eliciting biological activity. Understanding the pharmacophore is crucial for drug research and development, as it allows the design of new drugs. Malaria, a widespread disease, is commonly treated with chloroquine and artemisinin, but the emergence of parasite resistance limits their effectiveness.

Epileptic Targets and Drugs: A Mini-Review.

Background: Epilepsy is a neurological disease affected by an imbalance of inhibitory and excitatory signaling in the brain.

Introduction: In this disease, the targets are active in pathophysiology and thus can be used as a focus for pharmacological treatment.

Methods: Several studies demonstrated the antiepileptic effect of drugs acting on the following targets: N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, voltage-gated calcium channel (Cav), Gamma aminobutyric acid transporter type 1 (GAT1), voltage-gated sodium channels (Nav), voltage-gated potassium channel of the Q subfamily (KCNQ) and Gamma aminobutyric acid type A (GABAA) receiver.

Repercussions of COVID-19 on the daily lives of women living in a rural settlement.

Objective: To understand the repercussions of COVID-19 on women's daily lives in a rural settlement.

Methods: A qualitative study was conducted in a rural settlement of the Landless Workers' Movement (MST) in a municipality in Northeastern Brazil between January and March 2021. Forty-eight women participated through semi-structured interviews.

Nursing diagnoses, results, and interventions in the care for Covid-19 patients in critical condition.

Objective: To develop and validate a terminological subset of the International Classification for Nursing Practice for COVID-19 patients in critical care.

Method: This is a methodological study, which followed the guidelines of the Brazilian method, using the Basic Human Needs as a theoretical model. Content validation was performed by 25 specialist nurses using the Delphi technique.

Extubation in the pediatric intensive care unit: predictive methods. An integrative literature review.

For extubation in pediatric patients, the evaluation of readiness is strongly recommended. However, a device or practice that is superior to clinical judgment has not yet been accurately determined. Thus, it is important to conduct a review on the techniques of choice in clinical practice to predict extubation failure in pediatric patients.

Body and language: repercussions on a dysphasia case.

The human body is made of tissues and organs, and the body is mentioned by biology and medicine based on its anatomical and biomechanical architecture. However, there are different ways of understanding the human body. Based on the assumption that the body is the consistency of the speaker´s body-being, the psychoanalytic theory us that the body is crossed by language and affected by the word.

Environmental risk assessment (ERA) of pyriproxyfen in non-target aquatic organisms.

Pyriproxyfen (PPF) is a synthetic substance and an insect juvenile hormone agonist with growth regulating effect. It is used worldwide as a pesticide in agriculture and public health campaigns, including the control of Aedes aegypti proliferation. It has low volatility, high Kow value and high lability in aerobic aquatic systems but is considered persistent in anaerobic systems, with a half-life of 288.

Selected weight management interventions for military populations in the United States: a narrative report.

Overweight and obesity continues to be a significant public health burden in the US and particularly among military personnel. Although the US Department of Defense mandates standardized physical activity requirements for military members, incidence and prevalence of overweight and obesity among military personnel continue to increase. Each military department controls their own interventional strategies for physical fitness and weight control.