Publications by authors named "Jessica M Wiwczar"
The oxygen-evolving complex (OEC) of photosystem II (PSII) cycles through redox intermediate states S (i = 0-4) during the photochemical oxidation of water. The S state involves an equilibrium of two isomers including the low-spin S (LS-S) state with its characteristic electron paramagnetic resonance (EPR) multiline signal centered at g = 2.0, and a high-spin S (HS-S) state with its g = 4.
View Article and Find Full Text PDFPhotosystem II (PSII) of oxygenic photosynthetic organisms normally contains exclusively chlorophyll a (Chl a) as its major light-harvesting pigment. Chl a canonically consists of the chlorin headgroup with a 20-carbon, 4-isoprene unit, phytyl tail. We have examined the 1.
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- Defects in haem biosynthesis, particularly involving the enzyme ferrochelatase (Fech), lead to congenital anaemias due to impaired haem synthesis.
- Researchers used zebrafish models to identify the role of mitochondrial ATPase inhibitory factor 1 (Atpif1) in regulating Fech's efficiency for haem production.
- The study showed that Atpif1 deficiency disrupts mitochondrial pH and redox potential, decreasing Fech activity and ultimately resulting in anaemia across different species, highlighting its significance in red blood cell development and potential implications for human diseases.