Skeletal Muscle to Pancreatic β-Cell Cross-talk: The Effect of Humoral Mediators Liberated by Muscle Contraction and Acute Exercise on β-Cell Apoptosis.

Context: Mechanisms explaining exercise-induced β-cell health are unknown.

Objective: This study aimed to define the role of muscle contraction and acute exercise-derived soluble humoral mediators on β-cell health.

Design: In vitro models were used.