Publications by authors named "Jessica M Ketchum"

Article Synopsis
  • Memory impairments are a common issue after traumatic brain injury (TBI), and donepezil, a medication that helps with cognitive function, was evaluated for its effectiveness on these memory problems in a clinical trial called MEMRI-TBI-D.
  • The study involved 75 participants with severe memory issues related to TBI, who were split into two groups: one receiving donepezil and the other a placebo over 10 weeks; results showed significant memory improvement in those taking donepezil.
  • While donepezil was effective, it came with some side effects, notably diarrhea and nausea, and had a treatment-emergent adverse event rate of 46%, but overall, it demonstrated a favorable safety profile for treating memory impairments
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Article Synopsis
  • Study aimed to assess alexithymia prevalence in individuals with moderate-to-severe TBI one year post-injury, explore related demographic and injury factors, and analyze its links to emotional functioning and life satisfaction.
  • Among 196 participants, 14.3% had high levels of alexithymia, with tendencies observed for lower education levels in this group.
  • High alexithymia scores were linked to significant emotional dysregulation and post-traumatic stress, and moderately related to other negative emotional states and lower life satisfaction.
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Few studies have examined long-term mortality following traumatic brain injury (TBI) in a military population. This is a secondary analysis of a prospective, longitudinal study that examines long-term mortality (up to 10 years) post-TBI, including analyses of life expectancy, causes of death, and risk factors for death in service members and veterans (SM/V) who survived the acute TBI and inpatient rehabilitation. Among 922 participants in the study, the mortality rate was 8.

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Objective: To examine the unique contribution of alexithymia at 1 year after traumatic brain injury (TBI) to the prospective prediction of emotional and social health outcomes at 2 years after injury.

Design: Multicenter, longitudinal cohort study.

Setting: Data were collected during year 1 and year 2 postinjury follow-up interviews across 4 TBI Model System centers.

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Objectives: To compare 1-year mobility outcomes of individuals with traumatic motor incomplete spinal cord injury (miSCI) who participated in standardized locomotor training (LT) within the first year of injury to those who did not.

Methods: This retrospective case-control analysis conducted with six US rehabilitation hospitals used SCI Model Systems (SCIMS) data comparing 1-year postinjury outcomes between individuals with miSCI who participated in standardized LT to those who received usual care (UC). Participants were matched on age, gender, injury year, mode of mobility, and rehabilitation center.

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Objective: To determine if the interaction of opiate misuse and marijuana use frequency is associated with behavioral health outcomes.

Setting: Community.

Participants: Three thousand seven hundred fifty participants enrolled in the Traumatic Brain Injury Model Systems who completed the Pain Survey and had complete opioid use and marijuana use information.

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Article Synopsis
  • * Participants included 3,804 individuals aged 1 to 30 years post-injury, who completed a Pain Survey about 8 years after their injury.
  • * Results showed that individuals with current chronic pain faced significantly worse psychosocial outcomes, such as higher levels of PTSD, anxiety, and depression, and lower life satisfaction and community participation, compared to those with no pain or resolved past pain.
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Article Synopsis
  • The study assesses chronic pain prevalence in individuals with traumatic brain injury (TBI), finding that about 60% experience chronic pain at some point.
  • It compares three groups: those with current chronic pain, past chronic pain, and no chronic pain, noting that current pain is associated with worse functional outcomes.
  • The results highlight the need for more effective pain management and the inclusion of pain metrics in future research related to TBI.
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Objective: To define and characterize extreme phenotypes based on perceived improvement in pain for persons with chronic pain following traumatic brain injury (TBI).

Setting: Eighteen Traumatic Brain Injury Model System (TBIMS) Centers.

Participants: A total of 1762 TBIMS participants 1 to 30 years post-injury reporting chronic pain at their most recent follow-up interview.

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Objective: To define and characterize extreme phenotypes based on pain interference for persons with chronic pain following traumatic brain injury (TBI).

Setting: Eighteen Traumatic Brain Injury Model System (TBIMS) Centers.

Participants: A total of 1762 TBIMS participants 1 to 30 years post-injury reporting chronic pain at their most recent follow-up interview.

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Objective: To examine the relationship between extreme pain phenotypes (interference and improvement) and psychosocial outcomes among those with chronic pain after traumatic brain injury (TBI).

Setting: Community.

Participants: In total, 1762 TBI Model Systems (TBIMS) participants 1 to 30 years postinjury reporting chronic pain.

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The Extended Glasgow Outcome Scale (GOSE) is accepted as the primary outcome measure in registrational studies for traumatic brain injury (TBI). The Disability Rating Scale (DRS) is used to assess functional progress from initial acute injury, through rehabilitation and reintegration into the community and life. For these reasons, the DRS is an alternative measure for assessing meaningful global outcomes in chronic TBI.

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Traumatic brain injury (TBI) is a global health priority, associated with substantial burden. Historically conceptualised as an injury event with finite recovery, TBI is now recognised as a chronic condition that can affect multiple domains of health and function, some of which might deteriorate over time. Many people who have had a TBI remain moderately to severely disabled at 5 years, are rehospitalised up to 10 years post-injury, and have a reduced lifespan relative to the general population.

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Objective: To characterize demographic, pre-injury, and outcome data within the National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR) and Veterans Affairs (VA) Traumatic Brain Injury Model Systems (TBIMS) cohorts with severe traumatic brain injury (TBI) with no command-following ability at time of admission to acute rehabilitation.

Design: Retrospective cohort.

Setting: NIDILRR and VA TBI Model Systems (TBIMS) centers.

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Objective: To evaluate the safety and efficacy of treadmill training with virtual reality compared to treadmill training alone and standard of care balance and mobility treatment in chronic traumatic brain injury (TBI).

Participants And Design: Thirty-one individuals with chronic TBI with self-reported and objective balance deficits participated in a 4-week 12 session intervention of treadmill training with virtual reality, treadmill training alone, or standard of care overground therapy.

Outcome Measures: Primary measures included recruitment and enrollment rates, retention, tolerance to intervention, completeness of outcome measures, and adverse events.

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Objective: To examine the relationship between payer source for acute rehabilitation, residential median household income (MHI), and outcomes at rehabilitation discharge after traumatic brain injury (TBI).

Setting: Acute inpatient rehabilitation facilities.

Participants: In total, 8558 individuals enrolled in the Traumatic Brain Injury Model Systems (TBIMS) National Database who were admitted to inpatient rehabilitation between 2006 and 2019 and were younger than 64 years.

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Objectives: To evaluate associations between traumatic brain injury (TBI) and presence of health conditions, and to compare associations of health and cognition between TBI cases and controls.

Methods: This matched case-control study used data from the TBI Model Systems National Database (TBI cases) and Midlife in the United States II and Refresher studies (controls).  248 TBI cases were age-, sex-, race-, and education-matched without replacement to three controls.

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Objective: To describe alcohol use among younger military active duty service members and veterans (SMVs) in the first 5 years after traumatic brain injury (TBI) and examine whether differential alcohol use patterns emerge as a function of brain injury severity and active duty service at time of injury.

Setting: Veterans Affairs (VA) Polytrauma Rehabilitation Centers (PRCs).

Participants: In total, 265 SMVs enrolled in the VA Traumatic Brain Injury Model Systems (TBIMS) PRC national database.

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Context/objective: Spinal cord injury (SCI) often results in a significant loss of mobility and independence coinciding with reports of decreased quality of life (QOL), community participation, and medical complications often requiring re-hospitalization. Locomotor training (LT), the repetition of stepping-like patterning has shown beneficial effects for improving walking ability after motor incomplete SCI, but the potential impact of LT on psychosocial outcomes has not been well-established. The purpose of this study was to evaluate one year QOL, community participation and re-hospitalization outcomes between individuals who participated in a standardized LT program and those who received usual care (UC).

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The objective of this retrospective, longitudinal study was to investigate the prevalence of drinking within the recommended limits (i.e., low-risk drinking) after moderate/severe traumatic brain injury (TBI).

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Article Synopsis
  • This study investigates changes in function for individuals who experienced moderate-severe traumatic brain injury (TBI), focusing on a follow-up of 5 and 10 years post-injury with a sample size of 372 participants from a national database.
  • The findings reveal that while a majority of participants reported improvements in at least one functional area, a significant portion also experienced declines, indicating mixed outcomes over time.
  • Factors like age at injury, duration of post-traumatic amnesia, and mental health at the 5-year mark were linked to these functional changes, suggesting the need for ongoing monitoring and support for TBI survivors.
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Objective: To examine racial/ethnic disparities in community participation among veterans and active duty service members with traumatic brain injury (TBI).

Setting: Five Department of Veterans Affairs (VA) TBI Model Systems (TBIMS) Polytrauma Rehabilitation Centers (PRCs). Participants: Three hundred forty-two community-dwelling adults (251 White, 34 Black, and 57 Hispanic) with TBI enrolled in the VA TBIMS National Database who completed a 1-year follow-up interview.

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Objective: To examine the relationship between primary language and participation outcomes in English- and Spanish-speaking persons with complicated mild to severe traumatic brain injury (TBI) at 1 year post-injury.

Setting: Community following discharge from inpatient rehabilitation.

Participants: A total of 998 Hispanic participants with outcomes available at year 1 follow-up; 492 (49%) indicated English as their primary language and 506 (51%) indicated Spanish as their primary language.

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