Publications by authors named "Jessica M Hummel"
Article Synopsis
- Benzo[a]pyrene (BaP) is a harmful chemical linked to cancer, primarily ingested through diet in non-smokers.
- The U.S. EPA uses BaP to evaluate the risk of complex mixtures of similar chemicals, using data from high-dose animal studies to determine their potency.
- A study using advanced technology showed that consuming smoked salmon, which has high PAH levels, altered the body's absorption of BaP differently than canned salmon, indicating that the food's composition, not just its PAH content, affects how BaP is processed in the body.
The polycyclic aromatic hydrocarbon (PAH), dibenzo[def,p]chrysene (DBC; also known as dibenzo[a,l]pyrene), is a potent carcinogen in animal models and a class 2A human carcinogen. Recent investigations into DBC-mediated toxicity identified DBC as a potent immunosuppressive agent similar to the well-studied immunotoxicant 7,12-dimethylbenz[a]anthracene (DMBA). DBC, like DMBA, is bioactivated by cytochrome P450 (CYP) 1B1 and forms the reactive metabolite DBC-11,12-diol-13,14-epoxide (DBCDE).
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