Egress from host cells is an essential step in the lytic cycle of T. gondii and other apicomplexan parasites; however, only a few parasite secretory proteins are known to affect this process. The putative metalloproteinase toxolysin 4 (TLN4) was previously shown to be an extensively processed microneme protein, but further characterization was impeded by the inability to genetically ablate .
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2017
, a leading cause of bacterial gastroenteritis, is naturally competent. Like many competent organisms, restricts the DNA that can be used for transformation to minimize undesirable changes in the chromosome. Although can be transformed by -derived DNA, it is poorly transformed by the same DNA propagated in or produced with PCR.
View Article and Find Full Text PDFCampylobacter jejuni is a leading cause of bacterially derived foodborne illness. Human illness is commonly associated with the handling and consumption of contaminated poultry products. Three C.
View Article and Find Full Text PDFThe human pathogen Campylobacter jejuni is naturally competent for transformation with its own DNA. Genes required for efficient transformation in C. jejuni include those similar to components of type II secretion systems found in many Gram-negative bacteria (R.
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