Unlabelled: September 11, 2001 saw the dawn of the US-led global war on terror, a combined diplomatic, military, social, and cultural war on terrorist activities. Chemical, biological, radiological, nuclear, and high-yield explosives (CBRNE), as a group of tactics, are often the preferred weapons of terrorists across the globe. We undertook a survey of US medical schools to determine what their self-reported level of training for terrorist events encompasses during the four years of undergraduate medical education.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2012
Myosin Va (myoV) is a processive molecular motor that transports intracellular cargo along actin tracks with each head taking multiple 72-nm hand-over-hand steps. This stepping behavior was observed with a constitutively active, truncated myoV, in which the autoinhibitory interactions between the globular tail and motor domains (i.e.
View Article and Find Full Text PDFObjectives: The present study sought to develop 1-item and 2-item versions of subscales from the Multidimensional Pain Readiness to Change Questionnaire, Version 2 (MPRCQ2), a measure of readiness to adopt a variety of pain management and coping strategies commonly taught in multidisciplinary treatment programs.
Methods: One hundred and ninety patients with rheumatic diseases who entered a Rheumatology Day Program completed the MPRCQ2 and an additional criterion measure, the Pain Stages of Change Questionnaire (PSOCQ), before and after treatment. First one and then a second item that best represented each MPRCQ2 scale were selected based on: (1) the correlations between the items and their parent MPRCQ2 scale; (2) responsivity to change following treatment; (3) correlations of the items with the PSOCQ scales; and (4) authors' consensus of face validity and construct representativeness of items.
Most breast cancers exhibit brisk lipogenesis, and require it for growth. S14 is a lipogenesis-related nuclear protein that is overexpressed in most breast cancers. Sterol response element-binding protein-1c (SREBP-1c) is required for induction of lipogenesis-related genes, including S14 and fatty acid synthase (FAS), in hepatocytes, and correlation of SREBP-1c and FAS expression suggested that SREBP-1c drives lipogenesis in tumors as well.
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