Knockdown of Transmembrane Protein 150A () Results in Increased Production of Multiple Cytokines.

Lipopolysaccharide (LPS)-induced signaling through Toll-like receptor 4 (TLR4) is mediated by the plasma membrane lipid, phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P] and its derivatives diacylglycerol and inositol trisphosphate. Levels of PI(4,5)P are controlled enzymatically and fluctuate in LPS-stimulated cells. Recently, transmembrane protein 150A (TMEM150A/TM6P1/damage-regulated autophagy modulator 5) has been shown to regulate PI(4,5)P production at the plasma membrane by modifying the composition of the phosphatidylinositol 4-kinase enzyme complex.