Acute Rejection in Kidney Transplantation and Early Beginning of Tacrolimus.

Background: Although tacrolimus is an effective immunosuppressive drug used for preventing biopsy proven acute rejection (BPAR) in kidney transplanted patients, its nephrotoxicity may compromise renal function and lead to delayed initiation because of its side effects. This study aimed to evaluate the safety of early initiation of tacrolimus in the occurrence of BPAR during the first 90 days post transplant.

Methods: We conducted a retrospective cohort study involving 315 patients who underwent kidney transplantation from 2015 to 2017.

Alcohol consumption, new onset of diabetes after transplantation, and all-cause mortality in renal transplant recipients.

Background: Renal transplant recipients (RTR) are often advised to refrain from alcohol because of possible interaction with their immunosuppressive medication. Although moderate alcohol consumption is associated with reduced risk of diabetes and mortality in the general population, this is unknown for RTR. Therefore, we investigated the association of alcohol consumption with new onset of diabetes after transplantation (NODAT), mortality, and graft failure in RTR.