Publications by authors named "Jessica L Hernandez-Rivera"
Drug therapy for leishmaniasis remains a major challenge as currently available drugs have limited efficacy, induce serious side-effects and are not accessible to everyone. Thus, the discovery of affordable drugs is urgently needed. Chalcones present a great potential as bioactive agents due to simple structure and functionalization capacity.
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- The current treatments for Leishmaniasis and American trypanosomiasis are highly toxic and come with significant side effects, highlighting the need for safer alternatives.
- A series of new chalcones with prenyloxy or geranyloxy groups were synthesized and tested for their effectiveness against Leishmania mexicana and Trypanosoma cruzi, with some compounds showing over 50% metabolic inhibition.
- Compound 11 demonstrated strong activity against both parasites while also exhibiting a higher selectivity index compared to standard reference drugs, making it a promising candidate for further research.