Publications by authors named "Jessica L Gasparik"
J Inorg Biochem
February 2020
Article Synopsis
- Streptomyces coelicolor is a bacterium found in soil that produces antibiotics, but nickel accumulation can hinder its ability to create one specific antibiotic, undecylprodigiosin.
- The transcriptional repressor Nur, which regulates nickel uptake, has two metal-binding sites (M-site and Ni-site) that are crucial for its activity.
- Research using mutational studies and metal binding analysis has revealed a model showing how binding of metals to Nur influences its ability to bind DNA and activate its functions, with findings suggesting that binding to the Ni-site reduces DNA affinity despite cooperative metal binding.
