Publications by authors named "Jessica Kosut"

Article Synopsis
  • Research highlights a critical gap in understanding long COVID (PASC) in children and emphasizes the need for studies that define its characteristics in this age group.
  • The objective is to identify common prolonged symptoms in children aged 6 to 17 post-SARS-CoV-2 infection, examining differences between school-age kids and adolescents, as well as potential symptom clusters for future research.
  • A multicenter study involved nearly 5,000 participants, revealing that certain symptoms were significantly more prevalent in those with a history of COVID-19 compared to those without.
View Article and Find Full Text PDF

Importance: The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae of SARS-CoV-2 [PASC] or "Long COVID") in children and young adults remain unknown. Studies must address the urgent need to define PASC, its mechanisms, and potential treatment targets in children and young adults.

Observations: We describe the protocol for the Pediatric Observational Cohort Study of the NIH's REsearching COVID to Enhance Recovery (RECOVER) Initiative.

View Article and Find Full Text PDF
Article Synopsis
  • - The RECOVER-Pediatrics study aims to investigate the prevalence and long-term effects of Long COVID (PASC) in children and young adults, addressing the need for more research in this area.
  • - The study recruits caregiver-child pairs and young adults across 100+ sites in the U.S., focusing on a diverse group of participants with and without prior SARS-CoV-2 infections, and will collect data over several years through various tiers of assessments.
  • - The ultimate goal of the study is to understand the clinical trajectory, mechanisms, and sociodemographic factors related to pediatric PASC, thereby contributing to potential treatments and public health responses.
View Article and Find Full Text PDF

Research capacity building is a critical component of professional development for pediatrician scientists, yet this process has been elusive in the literature. The ECHO IDeA States Pediatric Clinical Trials Network (ISPCTN) seeks to implement pediatric trials across medically underserved and rural populations. A key component of achieving this objective is building pediatric research capacity, including enhancement of infrastructure and faculty development.

View Article and Find Full Text PDF

Cat scratch disease is known to be a generally benign, self-resolving illness associated with non-specific symptoms, including lymphadenopathy, fever, fatigue, anorexia, and headaches. However, it can also cause disseminated disease with a wide range of manifestations, including liver and spleen microabscesses, osteomyelitis, encephalitis, and uveitis. Eighteen pediatric cases of disseminated cat scratch disease at a single center in Hawai'i are described.

View Article and Find Full Text PDF

As one of 17 clinical sites of the Environmental influences on Child Health Outcomes (ECHO) IDeA States Pediatric Clinical Trials Network (ISPCTN), the Hawai'i IDeA Center for Pediatric and Adolescent Clinical Trials (HIPACT) was established in 2016 to participate in community-valued and scientifically-valid multi-center pediatric clinical trials to improve health and well-being of diverse multi-ethnic populations of Hawai'i. Hawai'i is home to large populations of diverse rural and underserved populations, including indigenous Hawaiian communities and immigrant populations of Pacific Islanders and Asians. Many of these communities experience significant health disparities, made worse by their geographic isolation and many socio-economic factors.

View Article and Find Full Text PDF

Cases of rare-earth magnet ingestions have been increasingly reported in the literature. However, these descriptions have focused on the severity of the injuries, rather than the clinical presentation and/or therapeutic approach. We report a series of eight children, ranging in age from 2 to 10 years, who ingested powerful rare-earth magnets.

View Article and Find Full Text PDF

Schistosomiasis is a parasitic disease that can cause significant illness in humans. While schistosomiasis is not found in the United States and other developed countries, 200 million people are infected worldwide. It is estimated that 400,000 infected persons immigrate to the United States and present to emergency departments with either acute or chronic schistosomiasis.

View Article and Find Full Text PDF