Effects of isolation housing stress and mouse strain on intravenous cocaine self-administration, sensory stimulus self-administration, and reward preference.

Sensory stimuli are natural rewards in mice and humans. Consequently, preference for a drug reward relative to a sensory reward may be an endophenotype of addiction vulnerability. In this study, we developed a novel behavioral assay to quantify the preference for intravenous drug self-administration relative to sensory stimulus self-administration.

Intravenous fentanyl self-administration in male and female C57BL/6J and DBA/2J mice.

The genetic mechanisms underlying fentanyl addiction, a highly heritable disease, are unknown. Identifying these mechanisms will lead to better risk assessment, early diagnosis, and improved intervention. To this end, we used intravenous fentanyl self-administration to quantify classical self-administration phenotypes and addiction-like fentanyl seeking in male and female mice from the two founder strains of the BXD recombinant inbred mouse panel (C57BL/6J and DBA/2J).

A Survey of Intestinal Parasites in South Florida.

populations are diminishing throughout their range due to urbanization, fragmentation, and poor habitat management. Increased population densities, poor habitat quality, and lack of fire may influence disease transmission. Parasite roles within wild tortoise populations are largely unknown; despite evidence these pathogens may pose significant health risks.

Prevalence and Levels of Parasitemia of sp. (Apicomplexa: Adeleorina) in Four Gopher Tortoise () Populations of South FLORIDA, USA.

prevalence (occurrence) and parasitemia (intensity) levels were documented in 67 individuals of the threatened gopher tortoise () for the first time in four South Florida, US, locations: Jonathan Dickinson State Park (JDSP), Pine Jog Preserve (PJP), Florida Atlantic University Preserve (FAUP), and Blazing Star Preserve (BSP). Sex ratios (males:females) per site were 0.44 at JDSP, 0.

Comparative Stability of Vitamin K1 Oral Liquids Prepared in Sterile Water for Injection and Stored in Amber Glass Bottles and Amber Plastic Syringes.

The purpose of this study was to evaluate the stability of vitamin K1 oral liquids in Sterile Water for Injection when stored in amber glass bottles and amber plastic syringes under refrigerated conditions. Four 100-mL batches of vitamin K1 in Sterile Water for Injection were prepared in amber glass bottles to protect from light. One of the batches was divided into 1-mL aliquots, using amber plastic oral syringes, and capped.

Stability of a pyrimethamine suspension compounded from bulk powder.

Purpose: Development of a stability-indicating high-performance liquid chromatography (HPLC) method for pyrimethamine analysis, with subsequent application of that method to assess the 90-day stability of a pyrimethamine suspension compounded from bulk USP-grade pyrimethamine powder, is described.

Methods: A stability-indicating method of HPLC with ultraviolet detection specific to pyrimethamine was developed according to pharmacopeial recommendations and validated. The method was applied to investigate the stability of a 2-mg/mL pyrimethamine suspension in a vehicle consisting of Ora-Plus and Ora-Sweet (Perrigo) over a period of 90 days.

Beyond-use dating of lidocaine alone and in two "magic mouthwash" preparations.

Purpose: Beyond-use dating (BUD) of lidocaine alone and in two "magic mouthwash" preparations stored in amber oral syringes at room temperature was determined.

Methods: Two formulations of mouthwash containing oral topical lidocaine 2% (viscous), diphenhydramine 2.5 mg/mL, and aluminum hydroxide-magnesium hydroxide-simethicone were prepared in 1:1:1 and 1:2.

Neural correlates of semantic activation spreading on the path to picture naming in adults who stutter.

Objective: On the path to picture naming, words that relate semantically to the pictured object become activated in the mental lexicon. We used a neuroscientific approach to investigate this semantic activation spreading process in adults who stutter (AWS).

Methods: Fourteen AWS and 14 adults who do not stutter (AWNS) completed a picture-word priming task.