Impact of a Quality Improvement Initiative on Increasing Height Measurement Among Children with Medical Complexity.

Background: This quality improvement project aimed to increase the rate of height measurement among children with medical complexity (CMC) seen for well-child visits.

Methods: Three interventions were implemented over 17 months. Retrospective chart review of well-child visits for patients 35 months through 18.

Advocating for Automatic Eligibility for Early Intervention Services for Children Exposed to Lead.

Lead poisoning remains one of the most prevalent and preventable environmental health hazards affecting children. Low-level lead exposure has been shown to significantly increase the risk of learning disabilities, behavioral problems, and developmental delay. It also has substantial social implications as lead toxicity disproportionately affects children from low-income, ethnic minority households.

Identification of HDAC6-Selective Inhibitors of Low Cancer Cell Cytotoxicity.

The histone deacetylases (HDACs) occur in 11 different isoforms, and these enzymes regulate the activity of a large number of proteins involved in cancer initiation and progression. The discovery of isoform-selective HDAC inhibitors (HDACIs) is desirable, as it is likely that such compounds would avoid some of the undesirable side effects found with the first-generation inhibitors. A series of HDACIs previously reported by us were found to display some selectivity for HDAC6 and to induce cell-cycle arrest and apoptosis in pancreatic cancer cells.