Publications by authors named "Jessica Healy Profitos"
Introduction: Preeclampsia is associated with acute neurological complications during pregnancy, but the subsequent risk of developing a neurological disorder is unclear. We determined if preeclampsia was associated with the long-term risk of neurological morbidity.
Methods: We conducted a longitudinal cohort study of 1,460,098 pregnant women with and without preeclampsia in Quebec, Canada, between 1989 and 2023.
The not-so-simple question of when or if to induce a term pregnancy.
Paediatr Perinat Epidemiol
November 2024
Objective: To evaluate the association between gestational trophoblastic disease and the subsequent risk of developing non-trophoblastic cancer.
Methods: We conducted a retrospective cohort study of 3084 women with gestational trophoblastic disease and 1 415 812 women with obstetric deliveries in Quebec, Canada, between 1989 and 2021. The main exposure was gestational trophoblastic disease, including hydatidiform moles, invasive moles, and gestational choriocarcinoma.
Objectives: We examined the ethnic origin of authors who published research articles in leading medical journals over the past 2 decades.
Study Design And Setting: We carried out a serial cross-sectional analysis of first and last authors who published original research articles in the British Medical Journal, Lancet, Journal of the American Medical Association, and New England Journal of Medicine in 2002, 2012, and 2022. The main outcome was the change in proportion of authors over time according to ethnic origin (Anglo, North/West European, South/West European, Asian, Arab and Middle Eastern, African), gender (male, female), and institutional affiliation in percentage points.
Objective: To investigate the risk of adverse neonatal events after a pregnancy complicated by severe maternal morbidity.
Study Design: We analyzed a population-based cohort of deliveries in Quebec, Canada, between 2006 and 2021. The main exposure measure was severe maternal morbidity, comprising life-threatening conditions such as severe hemorrhage, cardiac complications, and eclampsia.
Article Synopsis
- A study in Quebec examined over 1.4 million women to see if non-cardiac birth defects affect the risk of cardiovascular hospitalisation.
- Results showed that women with any birth defect had a significantly higher rate of cardiovascular hospitalisation compared to those without defects, with non-cardiac defects increasing the risk 1.61 times.
- Specific non-cardiac defects, especially urinary and central nervous system defects, were linked to higher risk, though cardiac defects posed the greatest risk overall.
Article Synopsis
- * Over 420,000 neonates from Quebec were analyzed, revealing that first trimester Covid-19 infections did not significantly increase the risk of birth defects (RR 1.07).
- * However, there was an increased risk of congenital microcephaly in late pandemic births compared to prepandemic births (RR 1.44), suggesting potential heightened awareness or detection of this anomaly during that time.
Background: We examined the risk of severe life-threatening morbidity in pregnant patients with Covid-19 infection.
Methods: We conducted a population-based study of 162,576 pregnancies between March 2020 and March 2022 in Quebec, Canada. The main exposure was Covid-19 infection, including the severity, period of infection (antepartum, peripartum), and circulating variant (wildtype, alpha, delta, omicron).
Background Hyperemesis gravidarum is associated with preeclampsia, but it is unclear whether hyperemesis gravidarum is a risk factor for cardiovascular disease. We assessed the long-term risk of cardiovascular disease in women who experienced hyperemesis gravidarum with or without preeclampsia. Methods and Results We analyzed a longitudinal cohort of 1 413 166 pregnant women in Quebec between 1989 and 2021.
View Article and Find Full Text PDFBackground: We identified patient characteristics associated with an increased risk of developing MIS-C.
Methods: We conducted a longitudinal cohort study of 1,195,327 patients aged 0-19 years between 2006 and 2021, including the first two waves of the pandemic (February 25-August 22, 2020 and August 23, 2020-March 31, 2021). Exposures included prepandemic morbidity, birth outcomes, and family history of maternal disorders.
Shifting age of child eating disorder hospitalizations during the Covid-19 pandemic.
J Child Psychol Psychiatry
August 2023
Article Synopsis
- - The study examined the impact of the Covid-19 pandemic on hospitalizations for eating disorders among children aged 10-19 in Quebec, revealing a significant increase during the pandemic waves compared to pre-pandemic rates.
- - Hospitalization rates rose from 5.8 per 10,000 before the pandemic to 6.5 during the first wave and 12.8 during the second wave, affecting both girls and boys, with specific spikes in admissions for younger and older age groups.
- - The findings suggest that both advantaged and disadvantaged youth experienced increased rates of eating disorder hospitalizations, with a notable early rise among girls aged 10-14 during the first wave and a subsequent rise in girls aged 15-19 during
Background: Multisystem inflammatory syndrome in adults (MIS-A) is an increasingly recognized complication of Covid-19. We assessed risk factors, clinical characteristics, and outcomes of patients with MIS-A compared with other inflammatory conditions.
Methods: We analyzed a cohort of patients ≥21 years hospitalized with MIS-A in Quebec, Canada between February 2020 and March 2021.
Aims: We assessed the impact of Covid-19 on gestational diabetes rates in Quebec, the pandemic epicenter of Canada.
Methods: We conducted a population-based study of 569,686 deliveries in Quebec between 2014 and 2021. We measured gestational diabetes rates in wave 1 (March 1, 2020-August 22, 2020) and wave 2 (August 23, 2020-March 31, 2021), compared with the prepandemic period.
Background: To synthesize existing evidence on Black-White disparities in the prevalence of severe cardiovascular maternal morbidity.
Methods: We searched MEDLINE, EMBASE, and CINAHL for observational studies published before July 31, 2021 that compared the risk of severe cardiovascular maternal morbidity between Black and White women. The outcome was severe cardiovascular maternal morbidity, including acute myocardial infarction, peripartum cardiomyopathy, and stroke during pregnancy, delivery, or postpartum.
Hyperemesis Gravidarum and the Potential for Cancer: A Longitudinal Cohort Study over Three Decades.
Cancer Epidemiol Biomarkers Prev
October 2022
Background: Our objective was to assess whether hyperemesis gravidarum is associated with the risk of endodermal, mesodermal, and ectodermal human chorionic gonadotropin (hCG) receptor+ cancer in women.
Methods: We performed a longitudinal cohort study of 1,343,040 women who were pregnant between 1989 and 2019 in Quebec, Canada. We identified women with and without hyperemesis gravidarum and followed them over time to capture incident cancers, grouped by embryonic germ cell layer of origin and organ hCG receptor positivity.
This study aims to systematically review disparities in outcomes of in vitro fertilization between Black and White patients. We searched CINAHL, Cochrane Library, EMBASE, Global Health, PsycINFO, PubMed, and Web of Science for observational studies published before August 2021. Outcomes included implantation, clinical pregnancy, spontaneous abortion, and live birth following in vitro fertilization in Black versus White patients.
View Article and Find Full Text PDFObjective: We studied the association between gestational diabetes mellitus and early versus late childhood cancer.
Research Design And Methods: We conducted a retrospective cohort study of 1 million children born between 2006 and 2019 in Quebec, Canada. We identified children who were exposed to gestational diabetes mellitus in utero and followed them from birth up to 14 years of age to identify new-onset cancers.
Article Synopsis
- Children born to mothers with autoimmune diseases may have a higher risk of being hospitalized for autoimmune disorders and allergies, but not for cancer.
- The study analyzed data from over a million Canadian children and found significant links between maternal autoimmune conditions and childhood health issues, particularly autoimmune diseases and allergies.
- However, when controlling for genetic and environmental factors through a sibling comparison, these associations weakened, suggesting that these risks might be more related to shared genes or environments rather than direct effects of maternal autoimmune diseases.
Background: Health outcomes of children in families affected by cancer are poorly understood. The authors assessed the risk of hospitalization in children who have a sibling with cancer.
Methods: This was a longitudinal cohort study in which 1600 children who had a sibling with cancer were matched to 32,000 children who had unaffected siblings in Quebec, Canada, from 2006 to 2020.