Chemoenzymatic Synthesis of Galectin Binding Glycopolymers.

Chemoenzymatic synthesis is an important strategy for the formation of glycopolymers. The use of a smaller number of traditional chemical steps and enzyme catalyzed reactions increases the yield of glycopolymer that can be produced by reducing the overall number of synthetic steps. In addition, chemoenzymatic routes are likely to be more accessible to those without a background in carbohydrate synthesis, making glycopolymers more available for studies across a broader range of scientists.

Cyclodextrin-functionalized chromatographic materials tailored for reversible adsorption.

Novel dendronized silica substrates were synthesized. First- and second- generation polyaryl ether dendrons were appended to silica surfaces. Using Cu(I) mediated cycloaddition "click" chemistry, β-cyclodextrin was tethered to the dendronized surfaces and to a nondendronized surface for comparison purposes.