Stemness, invasion, and immunosuppression modulation in recurrent glioblastoma using nanotherapy.

The recurrent nature of glioblastoma negatively impacts conventional treatment strategies leading to a growing need for nanomedicine. Nanotherapeutics, an approach designed to deliver drugs to specific sites, is experiencing rapid growth and gaining immense popularity. Having potential in reaching the hard-to-reach disease sites, this field has the potential to show high efficacy in combatting glioblastoma progression.

A meta-analysis of single visit pollination effectiveness comparing honeybees and other floral visitors.

Premise: Many animals provide ecosystem services in the form of pollination including honeybees, which have become globally dominant floral visitors. A rich literature documents considerable variation in single visit pollination effectiveness, but this literature has yet to be extensively synthesized to address whether honeybees are effective pollinators.

Methods: We conducted a hierarchical meta-analysis of 168 studies and extracted 1564 single visit effectiveness (SVE) measures for 240 plant species.

Transient Fetal Tachycardia After Intravenous Diphenhydramine Administration.

Background: Fetal tachycardia is attributable to a variety of etiologies, including an untreated maternal medical condition or an indicator of potential fetal compromise. Maternal medication administration may also affect the fetal heart rate.

Case: A 28-year-old nulliparous patient at 41 weeks of gestation was treated for pruritus with intravenous diphenhydramine after epidural administration of fentanyl.

Exploiting Electrostatic Interactions in Polymer-Nanoparticle Hydrogels.

Shear-thinning injectable hydrogels exploit dynamic noncovalent cross-links to flow upon applied stress and rapidly self-heal once the stress is relaxed. These materials continue to gather interest as they afford minimally invasive deployment in the body for a variety of biomedical applications. Here, we present rationally engineered polymer-nanoparticle (PNP) interactions based on electrostatic forces for the fabrication of self-assembled hydrogels with shear-thinning and self-healing properties.