Publications by authors named "Jessica F Tranovich"

Importance: Factors associated with clinical heterogeneity in Alzheimer disease (AD) lay along a continuum hypothesized to associate with tangle distribution and are relevant for understanding glial activation considerations in therapeutic advancement.

Objectives: To examine clinicopathologic and neuroimaging characteristics of disease heterogeneity in AD along a quantitative continuum using the corticolimbic index (CLix) to account for individuality of spatially distributed tangles found at autopsy.

Design, Setting, And Participants: This cross-sectional study was a retrospective medical record review performed on the Florida Autopsied Multiethnic (FLAME) cohort accessioned from 1991 to 2020.

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Article Synopsis
  • The study investigates the role of phosphorylated tau (pTau231) in the brain regions of individuals with varying stages of Alzheimer's disease (AD) to understand its correlation with cognitive decline.* -
  • Significant findings include the observation that increased pTau231 levels in the frontal cortex correspond with clinical severity of AD, while total tau levels were notably higher in individuals with amnestic mild cognitive impairment compared to those with full-blown AD.* -
  • The research suggests that the mislocalization of pTau231 is linked to disrupted glutamatergic signaling in specific brain areas, indicating that targeting pTau231 could be a promising strategy for early AD treatment.*
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Background: Advances in ultrasensitive detection of phosphorylated tau (p-tau) in plasma has enabled the use of blood tests to measure Alzheimer's disease (AD) biomarker changes. Examination of postmortem brains of participants with antemortem plasma p-tau levels remains critical to understanding comorbid and AD-specific contribution to these biomarker changes.

Methods: We analyzed 35 population-based Mayo Clinic Study of Aging participants with plasma p-tau at threonine 181 and threonine 217 (p-tau181, p-tau217) available within 3 years of death.

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Introduction: Comparison of tau (flortaucipir) positron emission tomography (FTP-PET) to autopsy is important to demonstrate the relationship of FTP-PET to neuropathologic findings.

Methods: Autopsies were performed on 26 participants who had antemortem FTP-PET. FTP-PET standardized uptake value ratios (SUVRs) were compared to autopsy diagnoses and Braak tangle stage.

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