Publications by authors named "Jessica F Araujo"
Article Synopsis
- COVID-19, caused by the SARS-CoV-2 virus, can range from mild to severe, with significant clinical complications linked to excessive immune responses and high levels of pro-inflammatory cytokines.
- This study investigated two gene variants, rs2494746 and rs1130214, in relation to severe COVID-19 outcomes, analyzing samples from 508 infected individuals to assess cytokine levels and genetic information.
- Findings revealed that the rs2494746-C allele is associated with worse disease outcomes, including increased severity, ICU admissions, and mortality, contributing valuable insights into how genetic factors affect immune responses to COVID-19.
Ecophysiological responses of Liolaemus arambarensis juveniles to experimental temperature variations.
Comp Biochem Physiol A Mol Integr Physiol
April 2024
Article Synopsis
- Climate change is negatively impacting biodiversity, particularly in ectothermic organisms like lizards, which rely on environmental temperatures for their physiological functions.
- The study focused on juvenile Liolaemus arambarensis lizards and measured their physiological responses to sudden temperature changes, highlighting how increasing temperatures led to oxidative stress and elevated stress hormone levels.
- Results suggest that such temperature fluctuations can disrupt the lizards' homeostasis and may compromise their growth and reproductive success, potentially increasing the risk of extinction for the species.
Background: The worst outcomes linked to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been attributed to the cytokine storm, which contributes significantly to the immunopathogenesis of the disease. The mammalian target of rapamycin (mTOR) pathway is essential for orchestrating innate immune cell defense including cytokine production and is dysregulated in severe Coronavirus Disease 2019 (COVID-19) individuals. The individual genetic background might play a role in the exacerbated immune response.
View Article and Find Full Text PDFMacrophages are myeloid cells that play an essential role in inflammation and host defense, regulating immune responses and maintaining tissue homeostasis. Depending on the microenvironment, macrophages can polarize to two distinct phenotypes. The M1 phenotype is activated by IFN-γ and bacterial products, and displays an inflammatory profile, while M2 macrophages are activated by IL-4 and tend to be anti-inflammatory or immunosupressive.
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